CHL1: A Protein Implicated in Cancer and Neurodegenerative Diseases

Target Name: CHL1

NCBI ID: G10752

CHL1

CHL1: A Protein Implicated in Cancer and Neurodegenerative Diseases

CHL1 (L1CAM2), a protein that belongs to the carcinoembryonic antigen (CEA) family, is a glycoprotein that is expressed in various tissues of the body, including the brain, lungs, heart, and gastrointestinal tract. It is a cell surface protein that is involved in cell adhesion, migration, and invasion, and has been implicated in several diseases, including cancer.

CHL1 is a 21-kDa protein that consists of two heavy chains and two light chains. The heavy chains contain four conserved domains: a N-terminal transmembrane domain, a single-stranded cytoplasmic domain, a hydrophobic tail, and a C-terminal protein-coding domain. The light chains contain a variable region that includes an N-terminal transmembrane domain, a single-stranded cytoplasmic domain, and a C-terminal protein-coding domain.

CHL1 is expressed in various tissues of the body and is involved in several physiological processes, including cell adhesion, migration, and invasion. It is highly expressed in the brain, where it is involved in the development and maintenance of neural cell cultures, and in the lungs, where it is involved in the regulation of cell death and survival. It is also expressed in the heart and gastrointestinal tract, where it is involved in the regulation of contractility and cell proliferation.

CHL1 has been implicated in several diseases, including cancer. For example, CHL1 has been shown to be overexpressed in various types of cancer, including lung, breast, and ovarian cancer. It has also been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Due to its involvement in several diseases, CHL1 has been considered as a potential drug target or biomarker. Several studies have suggested that CHL1 may be a useful target for cancer treatment, either alone or in combination with other therapies. For example, some studies have shown that inhibiting CHL1 can lead to a decrease in the growth and survival of cancer cells.

One potential mechanism by which CHL1 may be involved in cancer treatment is by inhibiting its role in cell adhesion and migration. CHL1 has been shown to be involved in the regulation of cell adhesion and migration, and it has been suggested that inhibiting its activity may be a useful strategy for cancer treatment. For example, some studies have shown that inhibiting CHL1 can lead to a decrease in the growth and survival of cancer cells.

Another potential mechanism by which CHL1 may be involved in cancer treatment is by targeting its role in the regulation of cell death and survival. CHL1 has been shown to be involved in the regulation of cell death and survival, and it has been suggested that inhibiting its activity may be a useful strategy for cancer treatment. For example, some studies have shown that inhibiting CHL1 can lead to a decrease in the growth and survival of cancer cells.

In addition to its potential role in cancer treatment, CHL1 is also a potential biomarker for cancer. Some studies have shown that CHL1 levels can be used as a biomarker for various types of cancer, including lung, breast, and ovarian cancer. It is also possible that CHL1 levels may be useful as a biomarker for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Overall, CHL1 is a protein that has been implicated in several diseases, including cancer. It is a cell surface protein that is involved in cell adhesion, migration, and invasion, and it has been suggested as a potential drug target or biomarker. Further research is needed to fully understand its role in

Protein Name: Cell Adhesion Molecule L1 Like

Functions: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity)

The "CHL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets