CHEK2: Regulating Cell Division and Apoptosis (G11200)

Target Name: CHEK2

NCBI ID: G11200

CHEK2

CHEK2: Regulating Cell Division and Apoptosis

CHEK2, also known as CHEK2 variant 3, is a protein that is expressed in various tissues throughout the body, including the liver, heart, kidneys, and intestines. It is a member of the checkpoint protein family, which is involved in regulating cell division and apoptosis.

CHEK2 plays a crucial role in ensuring that cells maintain a healthy balance of chromosomes, and it is involved in the regulation of DNA replication, transcription, and repair. It helps to ensure that the genetic material of cells is accurately copied and that any errors that occur during the replication process are repaired.

CHEK2 is also involved in the regulation of cell death, and it plays a role in the process of apoptosis. When a cell is no longer needed or is damaged beyond repair, CHEK2 helps to trigger the apoptosis process, which is a natural and essential mechanism for removing damaged or dysfunctional cells.

In addition to its role in regulating cell division and apoptosis, CHEK2 is also involved in the regulation of cellular signaling pathways. It is a key regulator of the DNA damage response, and it is involved in the repair of DNA double-strand breaks.

CHEK2 is also a potential drug target in cancer, as it has been shown to be involved in the regulation of cancer cell growth and survival. Studies have shown that CHEK2 is expressed in various types of cancer, including breast, ovarian, and colorectal cancer.

In addition to its potential as a drug target, CHEK2 is also a potential biomarker for cancer. Its expression has been shown to be associated with the development and progression of various types of cancer, and it has been used as a biomarker in a variety of clinical trials.

CHEK2 is also involved in the regulation of cellular processes that are important for maintaining tissue homeostasis. It is a regulator of the cytoskeleton, and it is involved in the regulation of cell migration and the maintenance of cell-cell adhesion.

In conclusion, CHEK2 is a protein that plays a crucial role in regulating cell division and apoptosis, and it is involved in the regulation of various cellular processes that are important for maintaining tissue homeostasis. Its potential as a drug target and biomarker make it an attractive target for researchers, and further studies are needed to fully understand its role in cancer development and progression.

Protein Name: Checkpoint Kinase 2

Functions: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978)

The "CHEK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHEK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets