CHRNA3: A G Protein-coupled Receptor Involved in Nicotine Addiction and Other Diseases

Target Name: CHRNA3

NCBI ID: G1136

CHRNA3

CHRNA3: A G Protein-coupled Receptor Involved in Nicotine Addiction and Other Diseases

CHRNA3 (Cholinergic Receptor, Nicotinic, Alpha Polypeptide 3) is a protein that is expressed in the central nervous system (CNS) and is involved in the neurotransmitter system. It is a G protein-coupled receptor that is known for its role in nicotine addiction and its potential as a drug target.

CHRNA3 is a 120 amino acid protein that is composed of an extracellular region, a transmembrane region, and an intracellular region. The extracellular region is made up of a single domain, which is responsible for the protein's ability to interact with ligands. The transmembrane region is made up of four transmembrane domains: an N-terminus, a T-terminus, a M-terminus, and an A-terminus. The intracellular region is made up of a single domain, which is responsible for the protein's ability to interact with intracellular signaling molecules.

CHRNA3 is a G protein-coupled receptor, which means that it is a protein that is involved in the transmission of signals from a ligand to the cell. G protein-coupled receptors are a family of transmembrane proteins that play a role in many different signaling pathways in the cell. They are characterized by a catalytic region, a transmembrane region, and an intracellular region.

CHRNA3 is involved in the neurotransmitter system, which is responsible for transmitting signals from the brain to the rest of the body. It is known for its role in nicotine addiction, which is a condition that is characterized by the use and dependence on nicotine. Studies have shown that CHRNA3 is involved in the reinforcement of drug and behavioral effects, which is thought to be a key aspect of nicotine addiction.

In addition to its role in nicotine addiction, CHRNA3 is also potential drug target. Studies have shown that CHRNA3 is involved in the regulation of many different signaling pathways in the cell, which makes it a promising target for drug development. For example, researchers have found that CHRNA3 is involved in the regulation of pain perception, anxiety, and depression.

In conclusion, CHRNA3 is a protein that is involved in the neurotransmitter system and is known for its role in nicotine addiction. It is also a potential drug target due to its involvement in many different signaling pathways in the cell. Further research is needed to fully understand the role of CHRNA3 in the neurotransmission and to develop effective treatments for nicotine addiction and other diseases.

Protein Name: Cholinergic Receptor Nicotinic Alpha 3 Subunit

Functions: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

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