ENTPD5: A Potential Drug Target for DNA Replication and Repair

Target Name: ENTPD5

NCBI ID: G957

ENTPD5

ENTPD5: A Potential Drug Target for DNA Replication and Repair

ENTPD5, also known as Guanosine-diphosphatase ENTPD5, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the ENTPD family, which is involved in the regulation of DNA replication and repair. ENTPD5 has been identified as a potential drug target and is the focus of ongoing research at the laboratory of Dr. Xinran Li at the University of California, San Diego.

The ENTPD family is composed of four proteins: ENTPD1, 鈥嬧?婨NTPD2, ENTPD3, and ENTPD5. All of these proteins share a conserved catalytic core and share a common mechanism of action, which involves the hydrolysis of a key substrate, guanosine triphosphate (GTP), to guanosine diphosphate (GDP). The ENTPD5 enzyme is a critical member of the ENTPD family, as it plays a crucial role in the regulation of DNA replication and repair.

DNA replication is a critical process that occurs in the cell nucleus. It is the process by which a cell inherits its genetic information from its parents and generates a copy of itself that will be passed on to the next generation. DNA replication is highly regulated, and various enzymes are involved in the process. The ENTPD family is one of the key enzymes involved in this regulation.

Guanosine triphosphate (GTP) is a key substrate for the ENTPD5 enzyme. It is a nucleotide that is involved in the regulation of various cellular processes, including DNA replication and protein synthesis. GTP is added to the active site of the ENTPD5 enzyme through a process called nucleotide addition. This process involves the addition of the nucleotide G1315 to the active site of the enzyme. Once G1315 is added, it is held in place by the side chain of the nucleotide, while the ENTPD5 enzyme is active.

The ENTPD5 enzyme is involved in the regulation of DNA replication and repair. It is a key enzyme in the DNA damage repair pathway, which is responsible for repairing damage to DNA that can occur during the process of DNA replication. ENTPD5 is also involved in the regulation of DNA replication in the cell cycle, as it plays a role in the progression of the cell cycle after DNA replication has occurred.

In addition to its role in DNA replication and repair, ENTPD5 is also involved in the regulation of protein synthesis. It is a key enzyme in the regulation of protein synthesis by the cell, as it plays a role in the transfer of amino acids from the cell's amino acid pool to the ribosome. This transfer is critical for the production of proteins, which are essential for the proper functioning of the cell.

ENTPD5 has been identified as a potential drug target due to its involvement in the regulation of DNA replication and repair. Many diseases are caused by disruptions in the regulation of DNA replication and repair, including cancer. Therefore, targeting ENTPD5 with drugs that can modulate its activity could be a promising strategy for the development of new treatments for a variety of diseases.

In conclusion, ENTPD5 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of DNA replication and repair. It is a key enzyme in the ENTPD family and has been identified as a potential drug target due to its involvement in the regulation of these critical cellular processes. Further research is needed to understand the full role of ENTPD5 in the regulation of DNA replication and repair and to explore its potential as a drug target.

Protein Name: Ectonucleoside Triphosphate Diphosphohydrolase 5 (inactive)

Functions: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:15698960, PubMed:10400613). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity)

The "ENTPD5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ENTPD5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets