KIF20B: A Potential Drug Target and Biomarker for Cancer (G9585)

Target Name: KIF20B

NCBI ID: G9585

KIF20B

KIF20B: A Potential Drug Target and Biomarker for Cancer

KIF20B is a protein that is expressed in various tissues of the body, including the skin, hair, and nervous system. It is also a cancer/testis antigen (CTA), which means it is associated with the development and progression of cancer in both cancer and testicular tissues. The identification of potential drug targets is an important aspect of cancer research, as it can lead to the development of more effective treatments. In this article, we will discuss KIF20B as a potential drug target and its potential as a biomarker for cancer.

Structure and Expression

KIF20B is a type-I transmembrane protein that is expressed in a variety of tissues, including the skin, hair, and nervous system. It has a molecular weight of 120 kDa and consists of two transmembrane regions and an intracellular region. The protein has a characteristic Hub-like structure that is composed of a nucleotide-binding oligomerization (NBO) domain and a cytoplasmic domain. The NBO domain is responsible for the protein's stability and functions as a scaffold, while the cytoplasmic domain is involved in the protein's localization and interaction with other cellular structures.

KIF20B is expressed in a variety of tissues, including the skin, hair, and nervous system.

Function and Interaction

KIF20B is involved in a number of cellular processes that are important for normal tissue growth and development. One of its functions is to regulate the cell cycle, which is the process by which cells grow, divide, and replicate their genetic material. KIF20B is a component of the spindle, which is the structure that pulls the chromosomes during cell division. It helps to ensure that the chromosomes are properly aligned and divided between new cells.

KIF20B is also involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. KIF20B helps to ensure that cells stick together in the correct place and stay there, which is important for the development and maintenance of tissues and organs.

In addition to its functions in regulating the cell cycle and cell adhesion, KIF20B is also involved in the regulation of inflammation. Inflammation is a natural response of the immune system to injury or infection. KIF20B is involved in the regulation of the inflammatory response by ensuring that immune cells are properly activated and that inflammation is not prolonged.

Drug Target Potential

KIF20B is a potential drug target because of its involvement in the regulation of the cell cycle, cell adhesion, and inflammation. Drugs that target these processes have been shown to be effective in treating a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In addition, KIF20B is also a cancer/testis antigen, which means that it can be used as a biomarker for the diagnosis and monitoring of cancer in both cancer and testicular tissues.

Biomarker Potential

KIF20B has the potential to be used as a biomarker for a variety of cancer types, including breast, ovarian, and prostate cancers. Its expression has been shown to be elevated in a variety of cancer tissues, which could make it an effective marker for the diagnosis and monitoring of these cancers. In addition, KIF20B has been shown to be decreased in the peripheral tissues of cancer patients, which could make it an effective marker for the diagnosis and monitoring of cancer-related systemic effects.

Conclusion

In conclusion, KIF20B is a protein that is expressed in various tissues of the body and is involved in a number of cellular processes that are important for normal tissue growth and development. Its involvement in the regulation of the cell cycle, cell adhesion, and inflammation makes it a potential drug target. In addition, KIF20B is also a cancer/testis antigen, which has the potential to be used as a biomarker for the diagnosis and monitoring of cancer. Further research is needed to fully understand the potential of KIF20B as a drug target and biomarker.

Protein Name: Kinesin Family Member 20B

Functions: Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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