KIR3DL3: A Potential Drug Target for Immune-Related Diseases (G115653)

Target Name: KIR3DL3

NCBI ID: G115653

KIR3DL3

KIR3DL3: A Potential Drug Target for Immune-Related Diseases

KIR3DL3 (Killer cell Ig-like receptor KIR3DL7) is a protein that is expressed in various cell types, including natural killer cells, T-cells, and B-cells. It is a member of the Ig-like receptor (ILR) family, which includes several different proteins that are involved in cell-mediated immunity. KIR3DL3 is of particular interest as a potential drug target or biomarker because of its unique structure and the role it plays in the immune system.

Structure and Function

KIR3DL3 is a 200-kDa protein that is composed of a 110-amino acid residue. It has a characteristic extracellular domain that is similar to that of other ILR proteins, with a cytoplasmic tail and a N-terminus that is involved in protein-protein interactions. The extracellular domain of KIR3DL3 contains a critical region that is involved in ligand binding, which is essential for its function in the immune system.

KIR3DL3 plays a critical role in the immune response by regulating the activity of natural killer cells. Natural killer cells are a type of immune cell that play a key role in eliminating infected or mutated cells from the body. KIR3DL3 is involved in regulating the cytokine production and activity of natural killer cells, which are critical for immune surveillance of the body.

In addition to its role in natural killer cells, KIR3DL3 is also involved in the regulation of T-cell and B-cell function. It has been shown to play a critical role in the regulation of T-cell helper 1 (Th1) cell development and function. KIR3DL3 has also been shown to regulate the activation and proliferation of B-cells, which are responsible for producing antibodies in response to foreign antigens.

KIR3DL3 is also of interest as a potential drug target because of its unique structure and the role it plays in the immune system. One of the challenges in developing new drugs for immune-related diseases is the development of resistance to drugs, which can limit the effectiveness of these drugs. KIR3DL3 is a potential drug target because its structure is distinct from that of other ILR proteins, which makes it less likely to have similar drug resistance patterns.

Drug Development

KIR3DL3 is a potential drug target that could be used to treat a variety of immune-related diseases, including autoimmune diseases, cancer, and infections. Several studies have shown that KIR3DL3 can be targeted by small molecules, including inhibitors of tyrosine kinase activity and inhibitors of protein-protein interactions.

One of the challenges in developing new drugs for immune-related diseases is the development of resistance to these drugs. KIR3DL3 is a potential drug target because its structure is distinct from that of other ILR proteins, which makes it less likely to have similar drug resistance patterns.

An inhibitor of KIR3DL3 has been shown to be effective in treating autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In these diseases, the immune system attacks the body's own tissues, leading to inflammation and damage. By blocking the activity of KIR3DL3, the immune system is able to reduce its activity and avoid attacking the body's own tissues.

Another potential drug for KIR3DL3 is an inhibitor of protein-protein interactions. These interactions can lead to the formation of immune complexes, which can contribute to the development of autoimmune diseases. By blocking protein-protein interactions, the immune system is able to reduce the formation of immune complexes, which can help to reduce the risk of developing autoimmune diseases.

Conclusion

KIR3DL3 is a protein that is expressed in various cell types, including natural killer cells, T-cells, and B-cells. It is a member of the Ig-like receptor (ILR) family,

Protein Name: Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3

Functions: Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis

The "KIR3DL3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KIR3DL3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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