KIF4A: A Potential Drug Target and Biomarker (G24137)

Target Name: KIF4A

NCBI ID: G24137

KIF4A

KIF4A: A Potential Drug Target and Biomarker

Kallikrein-related peptidases (KAPs), also known as kallikrein-protease, are a family of enzymes that regulate various cellular processes. The KIF4A gene is a member of this family and has been identified as a potential drug target and biomarker. This article will explore the biology of KIF4A, its potential drug targeting, and its role as a biomarker in various diseases.

Overview of KIF4A

Kallikrein-related peptidases (KAPs) are a family of enzymes that regulate various cellular processes, including cell signaling, inflammation, and tissue repair. These enzymes belong to the serine proteases, a group of enzymes that regulate protein levels and play a crucial role in maintaining cellular homeostasis.

KIF4A is a gene that encodes a protein known as Kallikrein-related peptidase 4A (KAP-4A). This protein is a 14-kDa protein that is expressed in various cell types, including neurons, muscle cells, and blood vessels. KIF4A is a member of the Kallikrein-related peptidases (KAPs) family and is involved in the regulation of various cellular processes, including cell signaling, inflammation, and tissue repair.

Potential Drug Target

KIF4A has been identified as a potential drug target due to its involvement in various cellular processes that are crucial for human health. One of the main targets of KIF4A is the regulation of matrix metalloprotegerin (MMP) signaling. MMP is a protein that plays a role in tissue repair and regeneration, and its levels are regulated by KIF4A.

KIF4A has been shown to regulate the activity of the MMP-2 enzyme, which is involved in the degradation of extracellular matrix (ECM) components. This contributes to the regulation of tissue repair and regeneration, and is crucial for the development and maintenance of tissues and organs.

In addition to its role in MMP signaling, KIF4A has also been shown to regulate the activities of other enzymes involved in cellular signaling, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and inflammation, and is a key factor in the development and maintenance of tissues and organs.

Potential Biomarker

KIF4A has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This is because KIF4A is involved in the regulation of various cellular processes that are disrupted in these diseases, providing a potential target for the development of new treatments.

For example, KIF4A has been shown to be involved in the regulation of cancer cell growth and metastasis. In addition, KIF4A has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These diseases are characterized by the progressive degeneration of brain cells, and the regulation of KIF4A may be involved in the development and progression of these diseases.

KIF4A has also been shown to be involved in the regulation of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. These diseases are characterized by the production of antibodies that target the body's own tissues, leading to inflammation and damage. The regulation of KIF4A by these diseases may be involved in the development and progression of these diseases.

Conclusion

In conclusion, KIF4A is a gene that encodes a protein involved in various cellular processes that are crucial for human health. The regulation of MMP signaling and the TGF-β pathway by KIF4A is a potential drug target, and its potential as a biomarker for

Protein Name: Kinesin Family Member 4A

Functions: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity)

The "KIF4A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KIF4A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets