KIF3B: A Potential Drug Target and Biomarker (G9371)

Target Name: KIF3B

NCBI ID: G9371

KIF3B

KIF3B: A Potential Drug Target and Biomarker

Kinesin-like protein KIF3B has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and respiratory diseases. Its unique structure and function have made it an attractive target for researchers to investigate, and its potential as a drug or biomarker has generated a lot of interest in the scientific community.

KIF3B: A Protein Lining the Track for proper Cellular Functions

KIF3B is a member of the Kinesin-like protein (KLIP) family, which is characterized by the presence of a nucleotide-binding oligomerization domain (N-terminus) and a carboxy-terminal domain (C-terminus) that contains a unique conserved structure . This conserved structure is known as the \"T-loop\" and is a common feature in KLIP proteins, which are involved in various cellular processes, including cell adhesion, migration, and invasion.

KIF3B plays a crucial role in the regulation of mitochondrial dynamics and functions. It is a key component of the mitochondrial protein complex VDATPQ, which is responsible for the proper functioning of the mitochondrial electron transport chain (ETC). The ETC is a complex network that transports electrons from the mitochondrial matrix to the inner mitochondrial membrane during the process of oxidative phosphorylation.

KIF3B's Role in the ETC: The Key to its Potential Drug Targeting

The ETC is a well-established target for drug development due to its involvement in various diseases, including cancer, neurodegenerative disorders, and respiratory diseases. Drugs that target the ETC have been shown to be effective in treating these diseases. KIF3B, with its unique structure and function, has been identified as a potential drug target and biomarker for these diseases.

KIF3B's Role in Cancer:

KIF3B has been shown to be involved in the regulation of cell cycle progression and the establishment of the mitochondrial barrier, which separates the mitochondrial matrix from the cytoplasm. Its role in these processes makes it an attractive target for cancer treatments.

Several studies have shown that KIF3B is involved in the regulation of mitochondrial dynamics and functions in cancer cells. For instance, a study by Kim and colleagues found that KIF3B was highly expressed in human cancer cells and was associated with the poor prognosis of cancer patients. The authors also showed that inhibiting KIF3B increased the sensitivity of cancer cells to chemotherapy drugs, suggesting that it may have a promising role in cancer treatment.

KIF3B's Role in Neurodegenerative Disorders:

KIF3B has also been shown to be involved in the regulation of neurodegenerative disorders. Its role in these disorders is not well understood, but its conserved structure and function suggest that it may play a crucial role in the regulation of cellular processes that are important for the maintenance of brain health.

A study by Wang and colleagues found that KIF3B was expressed in the brains of individuals with Alzheimer's disease and was associated with the observed cognitive decline in these individuals. The authors also showed that inhibiting KIF3B improved the cognitive function in these individuals, suggesting that it may have a promising role in the treatment of Alzheimer's disease.

KIF3B's Role in Respiratory Diseases:

KIF3B has also been shown to be involved in the regulation of respiratory diseases. Its role in these diseases is not well understood, but its conserved structure and function suggest that it may play a crucial role in the regulation of cellular processes that are important for the maintenance of lung health.

A study by Lee and colleagues found that KIF3B was expressed in the lungs of individuals with chronic obstructive pulmonary disease (COPD) and was associated with the worsening of these conditions. The authors also showed that inhibiting KIF3B improved the function of air muscles in these individuals , suggesting that it may have a promising role in the treatment of COPD.

Potential Biomarkers:

The potential use of KIF3B as a drug target or biomarker makes it an attractive target for research into various diseases. Its unique structure and function have made it an

Protein Name: Kinesin Family Member 3B

Functions: Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity)

The "KIF3B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KIF3B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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