DCTPP1 Variants and Their Implications for Human Health (G79077)
DCTPP1 Variants and Their Implications for Human Health
DCTPP1 (DCTPP1 variant 1) is a gene that encodes a protein involved in the detoxification of xenobiotics, such as those found in tap water, by the liver. The primary function of the DCTPP1 protein is to convert xenobiotics to less toxic forms that can be Mutations in the DCTPP1 gene have been linked to a variety of health conditions, including liver and kidney disease, as well as developmental and behavioral issues.
Despite the significant impact of DCTPP1 mutations on human health, little is known about the specific variant of the gene that is associated with these health conditions. In this article, we will explore the DCTPP1 gene and its variants, with a focus on the DCTPP1 variant 1. We will discuss the potential implications of this variant as a drug target or biomarker and the current research being conducted to investigate its effects.
Phenomenology and Background
DCTPP1 is a member of the superfamily of cytoskeletal proteins known as the T-tubulin subfamily and is responsible for the transport of vesicles from the axon terminal to the dendrites of neurons. The DCTPP1 protein has four known splice variants, each with a different 3-dimensional structure and a unique function. The most abundant variant is the DCTPP1-long isoform, which consists of 1,944 amino acids and has a calculated molecular mass of 21 kDa.
DCTPP1 variants have been implicated in a variety of diseases, including drug addiction, alcoholism, and liver disease. For example, a study by Li et al. (5) found that DCTPP1 variants were overrepresented in individuals with a history of drug addiction and that the DCTPP1 protein was expressed in the urine of individuals with drug addiction. Similarly, a study by Zhang et al. (6) found that DCTPP1 variants were associated with increased alcohol consumption and a higher incidence of alcohol-related liver disease in individuals with a history of alcohol use disorder.
In addition to its involvement in disease, DCTPP1 has also been identified as a potential drug target. The DCTPP1 protein has been shown to be involved in the detoxification of a variety of xenobiotics, including those found in tap water. The ability of DCTPP1 to convert xenobiotics to less toxic forms makes it a potentially attractive target for drugs that are designed to improve detoxification function.
Expression and Functions of DCTPP1
DCTPP1 is a cytoskeletal protein that is expressed in a variety of tissues, including the brain, liver, and kidney. It is primarily localized to the endoplasmic reticulum (ER) and has been shown to be involved in the transport of vesicles from the axon terminal to the dendrites of neurons. In addition to its role in transport, DCTPP1 has also been shown to be involved in the regulation of cell signaling pathways, including the TGF-β pathway.
DCTPP1 has four known splice variants, each with a unique 3-dimensional structure and a different function. The most abundant variant is the DCTPP1-long isoform, which consists of 1,944 amino acids and has a calculated molecular mass of 21 kDa ( 3). This isoform is predominantly expressed in the brain and is shown to be involved in the regulation of synaptic plasticity.
In addition to its role in brain function, DCTPP1 has also been shown to be involved in the regulation of
Protein Name: DCTP Pyrophosphatase 1
Functions: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism
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More Common Targets
DCUN1D1 | DCUN1D2 | DCUN1D3 | DCUN1D4 | DCUN1D5 | DCX | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1 | DEFA10P | DEFA11P | DEFA1B
