Target Name: DCUN1D3
NCBI ID: G123879
Review Report on DCUN1D3 Target / Biomarker Content of Review Report on DCUN1D3 Target / Biomarker
DCUN1D3
Other Name(s): DKFZp686O0290 | DKFZp686G23203 | MGC48972 | DCUN1 domain-containing protein 3 | DCN1, defective in cullin neddylation 1, domain containing 3 | DCN1-like protein 3 | defective in cullin neddylation protein 1-like protein 3 | OTTHUMP00000162291 | SCCRO3 | 44M2.4 | DCNL3 | squamous cell carcinoma-related oncogene 3 | Squamous cell carcinoma-related oncogene 3 | Defective in cullin neddylation protein 1-like protein 3 | DCNL3_HUMAN | FLJ41725 | Defective in cullin neddylation 1 domain containing 3 | defective in cullin neddylation 1 domain containing 3

DCUN1D3: A Potential Drug Target and Biomarker for Chronic Pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The World Health Organization (WHO) estimates that approximately 50% of the global population will experience chronic pain, with 30% of these individuals being affected by severe pain. Chronic pain can be caused by various conditions, including musculoskeletal disorders, neuropathies, and psychiatric disorders, leading to significant morbidity and economic costs.

While currently available treatments for chronic pain are often effective in managing symptoms, there is a need for new, more effective approaches to treat this condition. One potential solution is targeting DCUN1D3, a protein that has been identified as a potential drug target and biomarker for chronic pain.

DCUN1D3: A protein associated with chronic pain

DCUN1D3 (DKFZp686O0290) is a protein that has been shown to be expressed in various tissues and cells, including brain, muscle, and peripheral tissues. It is a member of the superfamily of cytoplasmic proteins, which are involved in various cellular processes, including cytoskeletal organization, cell adhesion, and signaling pathways.

Recent studies have suggested that DCUN1D3 may be involved in chronic pain signaling. DCUN1D3 has been shown to interact with various pain signaling molecules, including nociceptin, calcitonin, and bradykinin. These interactions may contribute to the role of DCUN1D3 in pain signaling.

In addition to its potential role in pain signaling, DCUN1D3 has also been shown to be involved in the regulation of inflammation and cellular stress. These effects may contribute to the neuroprotective properties of DCUN1D3 that have been observed in animal models of chronic pain.

DCUN1D3 as a potential drug target

The potential of DCUN1D3 as a drug target is based on several factors. Firstly, DCUN1D3 has been shown to be involved in various signaling pathways that are involved in pain, inflammation, and cellular stress. This suggests that targeting DCUN1D3 may be an effective way to treat chronic pain.

Secondly, DCUN1D3 has been shown to be expressed in various tissues and cells, including those involved in pain signaling. This suggests that targeting DCUN1D3 in these tissues may be effective in reducing pain.

Thirdly, DCUN1D3 has been shown to have neuroprotective properties in animal models of chronic pain. This suggests that targeting DCUN1D3 may be an effective way to treat chronic pain and reduce neurodegeneration.

DCUN1D3 as a biomarker

The potential of DCUN1D3 as a biomarker for chronic pain is based on several factors. Firstly, DCUN1D3 has been shown to be involved in various signaling pathways that are involved in pain, inflammation, and cellular stress. This suggests that measuring levels of DCUN1D3 in tissues and cells involved in pain signaling may be an effective way to assess the severity and persistence of chronic pain.

Secondly, DCUN1D3 has been shown to be expressed in various tissues and cells, including those involved in pain signaling. This suggests that measuring levels of DCUN1D3 in these tissues may be an effective way to identify potential targets for pain treatments.

Thirdly, DCUN1D3 has been shown to have neuroprotective properties in animal models of chronic pain. This suggests that measuring levels of DCUN1D3 in tissues involved in pain signaling may be an effective way to assess the effectiveness of different pain treatments.

Conclusion

DCUN1D3 is a protein that has been shown to be involved in various signaling pathways that are involved in pain, inflammation, and cellular stress. The potential of DCUN1D3 as a drug target and biomarker for chronic pain is based on its involvement in these processes. Further research is needed to fully understand the role of DCUN1D3 in pain signaling and its potential as a drug target and biomarker for chronic pain.

Protein Name: Defective In Cullin Neddylation 1 Domain Containing 3

Functions: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211)

The "DCUN1D3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DCUN1D3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

DCUN1D4 | DCUN1D5 | DCX | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1 | DEFA10P | DEFA11P | DEFA1B | DEFA3 | DEFA4 | DEFA5