Target Name: DCTN4
NCBI ID: G51164
Review Report on DCTN4 Target / Biomarker Content of Review Report on DCTN4 Target / Biomarker
DCTN4
Other Name(s): DCTN4 variant 1 | Dynactin subunit 4, transcript variant 1 | Dynactin p62 subunit | DCTN4_HUMAN | dynactin 4 (p62) | Dyn4 | dynactin subunit 4 | Dynactin subunit 4 | P62 | dynactin p62 subunit | dynactin subunit p62 | Dynactin subunit 4 (isoform a) | Dynactin subunit p62 | DYN4

Dopamine Transporter Subtype 4: Potential Drug Target Or Biomarker

Dopamine transporter subtype 4 (DCTN4) is a protein that plays a crucial role in the transportation of dopamine from the brain to other parts of the body. DCTN4 is a single transmembrane protein that consists of four subunits. It is expressed in many different tissues and cells throughout the body, including the brain, neurons, and endothelial cells.

DCTN4 is known to be involved in the regulation of dopamine release and uptake. It has been shown to play a role in the development and progression of various neurological disorders, including Parkinson's disease, addiction, and schizophrenia.

Recent studies have also suggested that DCTN4 may be a potential drug target or biomarker. For example, scientists have found that blocking DCTN4 with a small molecule inhibitor can reverse the effects of dopamine agonists in animal models of Parkinson's disease.

DCTN4 is also a target for some drugs used to treat addiction, such as naltrexone and Valtorin.

The structure and function of DCTN4

The structure of DCTN4 is highly conserved across different species, with similar conserved amino acid residues and patterns of localization. It has four transmembrane domains, each of which is characterized by a unique arrangement of amino acids.

The first transmembrane domain is composed of a single alpha helix and a beta-sheet. The second transmembrane domain is a loop region that contains a unique amino acid sequence, known as the \"dopamine-binding loop.\" This loop is thought to play a role in the regulation of dopamine transport.

The third transmembrane domain is a long coiled-coil region that is responsible for maintaining the protein's stability and localization to the endoplasmic reticulum.

The fourth transmembrane domain is a short cytoplasmic region that is involved in the regulation of dopamine uptake and release.

Function

DCTN4 is involved in the regulation of dopamine release and uptake from the endosteum, where it is expressed in the peri-synaptic terminal field of dopamine-producing neurons. It has been shown to play a role in the regulation of dopamine release in response to various environmental stimuli, such as changes in temperature or neurotransmitter levels.

DCTN4 is also involved in the regulation of dopamine uptake and release in response to dopamine agonists. These agonists include drugs that bind to DCTN4 and enhance dopamine release.

In addition to its role in dopamine transport, DCTN4 is also involved in the regulation of other neurotransmitter systems. For example, it has been shown to play a role in the regulation of neurotrophic factor (NTF) release, which is a protein that supports the survival and growth of neural cells.

DCTN4 is also involved in the regulation of pain perception and neuroinflammation.

Despite its importance in the regulation of dopamine transport and other neurotransmitter systems, DCTN4 is not well understood. little is known about the specific mechanisms of its function, and much of its behavior is still the subject of ongoing research.

Drug targeting

Recent studies have suggested that DCTN4 may be a potential drug target or biomarker. For example, scientists have found that blocking DCTN4 with a small molecule inhibitor can reverse the effects of dopamine agonists in animal models of Parkinson's disease.

Additionally, DCTN4 has been shown to be involved in the regulation of pain perception and neuroinflammation, making it an attractive target for drugs that are used to treat these conditions.

Other potential drug targets for DCTN4 include those that target the regulation of dopamine release and uptake, such as neurotransmitter antagonists, and those that target the regulation of pain perception and neuroinflammation, such as nonsteroidal anti-inflammatory drugs (NSAIDs).

Conclusion

Dopamine transporter subtype 4 (DCTN4) is a protein that plays a crucial role in the transportation of dopamine from the brain to other parts of the body. Recent studies have suggested that DCTN4 may be a potential drug target or biomarker, and that it may be involved in the regulation of various neurological disorders, including Parkinson's disease, addiction, and schizophrenia. Additionally, DCTN4 is also involved in the regulation of dopamine release and uptake, making it an attractive target for drugs that are used to treat pain perception and neuroinflammation. Further research is needed to fully understand the role of DCTN4 and its potential as a drug target.

Protein Name: Dynactin Subunit 4

Functions: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules

The "DCTN4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DCTN4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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DCTN5 | DCTN6 | DCTPP1 | DCUN1D1 | DCUN1D2 | DCUN1D3 | DCUN1D4 | DCUN1D5 | DCX | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1