DCUN1D5 as A Potential Drug Target and Biomarker (G84259)
DCUN1D5 as A Potential Drug Target and Biomarker
Defective in cullin neddylation 1 domain containing 5 (DCUN1D5) is a gene that encodes a protein known as DCUN1D5. DCUN1D5 is a protein that is expressed in various tissues and cells throughout the body, including the brain, heart, and skeletal muscles. It is a key regulator of the cullin neddylation 1 (Cullin-Neddylation) pathway, a critical signaling pathway that regulates protein synthesis and degradation. DCUN1D5 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.
The Cullin-Neddylation pathway is a complex protein-protein interaction pathway that involves the cullin protein and the neddylation factors. The cullin protein is a key regulator of protein synthesis and degradation, and the neddylation factors are proteins that bind to the cullin protein and enhance its stability. The Cullin-Neddylation pathway plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and stress resistance.
DCUN1D5 is a protein that is expressed in various tissues and cells throughout the body, including the brain, heart, and skeletal muscles. It is a key regulator of the Cullin-Neddylation pathway and has been shown to play a crucial role in the regulation of cellular processes. DCUN1D5 has been shown to interact with various neddylation factors, including HDACs (hypoxia-inducible hypoxia) and SIRTIs (Sirtuin-like intracellular hypoxia).
In addition to its role in the Cullin-Neddylation pathway, DCUN1D5 has also been shown to play a role in the regulation of cellular processes that are independent of the Cullin-Neddylation pathway. regulation of cell survival and apoptosis, as well as in the regulation of cellular processes that are dependent on the Cullin-Neddylation pathway, such as cell growth and differentiation.
As a potential drug target, DCUN1D5 has been shown to have a variety of potential therapeutic applications. For example, DCUN1D5 has been shown to be a potential therapeutic target for a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. DCUN1D5 has also been shown to be a potential therapeutic target for cancer, as it has been shown to play a role in the regulation of cancer cell growth and survival.
In addition to its potential therapeutic applications, DCUN1D5 has also been shown to have a variety of potential biomarker applications. For example, DCUN1D5 has been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. DCUN1D5 has been shown to be expressed in various tissues and cells throughout the body, including the brain, heart, and skeletal muscles, which makes it a potential biomarker for a variety of diseases.
Conclusion
Defective in cullin neddylation 1 domain containing 5 (DCUN1D5) is a protein that is known to play a crucial role in the regulation of cellular processes that are independent of the Cullin-Neddylation pathway. DCUN1D5 has been shown to interact with various neddylation factors, including HDACs and SIRTIs, and has been shown to play a role in the regulation of cell survival and apoptosis. As a potential drug target and biomarker, DCUN1D5 has a variety of potential therapeutic applications, including the treatment of
Protein Name: Defective In Cullin Neddylation 1 Domain Containing 5
Functions: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26906416, PubMed:23201271, PubMed:19617556). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928)
The "DCUN1D5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DCUN1D5 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
DCX | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8 | DEFA1 | DEFA10P | DEFA11P | DEFA1B | DEFA3 | DEFA4 | DEFA5 | DEFA6 | DEFA7P
