STK25: A Potent Drug Target and Potential Biomarker for Cancer

Target Name: STK25

NCBI ID: G10494

STK25

STK25: A Potent Drug Target and Potential Biomarker for Cancer

Serine/threonine-protein kinase (STK) 25 (STK25) is a protein that plays a crucial role in cell signaling pathways, particularly in the regulation of cell cycle progression and apoptosis. STK25 is a member of the STK family of kinases, which are known to be involved in the regulation of cell growth, differentiation, and survival. The identification and characterization of STK25 as a potential drug target and biomarker for cancer has significant implications for the development of new therapeutic strategies.

Structure and Function

STK25 is a 21-kDa protein that consists of 241 amino acid residues. It has a unique catalytic mechanism, as it is a serine protein that can catalyze the phosphorylation of serine residues at specific threonine residues. This unique feature allows STK25 to activate multiple signaling pathways, including the PI3K/Akt pathway, the MAPK/ERK pathway, and the FGFR signaling pathway.

STK25 is involved in the regulation of various cellular processes, including cell growth, apoptosis, and cell cycle progression. It has been shown to play a critical role in the regulation of cell cycle progression, where it is involved in the metaphase-anaphase transition and the G1-S transition. In addition, STK25 is involved in the regulation of apoptosis, which is a critical programmed cell death that is necessary for the development and maintenance of multicellular organisms.

STK25 has also been shown to play a role in cell signaling pathways, including the regulation of angiogenesis, cell adhesion, and neurotransmitter release. These functions are critical for the development and maintenance of tissues and organs, and the deregulation of STK25 has been implicated in various diseases, including cancer.

Drug Target Potential

The identification of STK25 as a potential drug target has significant implications for the development of new therapeutic strategies for cancer. By inhibiting the activity of STK25, researchers can reduce the cell proliferation and survival of cancer cells, leading to a reduction in the incidence and progression of cancer.

In addition, the inhibition of STK25 has been shown to be effective in preclinical models of cancer, including the inhibition of STK25 has led to a reduction in the growth of cancer cells in xenograft models and in vitro models. These results suggest that STK25 may be an effective target for cancer therapy.

Biomarker Potential

The identification of STK25 as a potential biomarker for cancer also has significant implications for the development of new diagnostic tests for cancer. The regulation of STK25 by various signaling pathways makes it an attractive target for the development of new biomarkers that can be used to diagnose and monitor the progression of cancer.

For example, the levels of STK25 have been shown to be elevated in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, the inhibition of STK25 has been shown to reduce the growth of cancer cells in xenograft models and in vitro models, which may be used as a positive control for the detection of cancer biomarkers.

Conclusion

In conclusion, STK25 is a protein that plays a critical role in the regulation of cell signaling pathways, including the regulation of cell cycle progression and apoptosis. The identification and characterization of STK25 as a potential drug target and biomarker for cancer has significant implications for the development of new therapeutic strategies for cancer. Further research is needed to fully understand the role of STK25 in cancer biology and to develop effective biomarkers for cancer diagnosis and monitoring.

Protein Name: Serine/threonine Kinase 25

Functions: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration

The "STK25 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STK25 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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