SKIC8: Key Regulator of Hair and Skin Development (G80349)

Target Name: SKIC8

NCBI ID: G80349

SKIC8

SKIC8: Key Regulator of Hair and Skin Development

SKIC8, also known as Ski complex subunit Rec14, is a protein that is expressed in the skin and hair, and is known for its role in the development and maintenance of hair and skin. The protein is composed of 194 amino acids and has a calculated molecular weight of 21 kDa. It is found in the skin layer, in the hair matrix, and in the epidermis.

SKIC8 is a member of the Ski complex, which is a group of proteins that are involved in the regulation of cell growth and differentiation. The Ski complex is composed of four subunits, Rec12, Rec13, Rec14, and Rec15. These subunits are involved in the formation of the complex and in the regulation of various cellular processes, including cell growth, differentiation, and angiogenesis.

SKIC8 is one of the proteins that is part of the Ski complex. It is a key regulator of the growth and differentiation of hair and skin cells. It is involved in the formation of the hair follicle and the development of the hair matrix. It also plays a role in the regulation of skin cell turned regeneration.

SKIC8 is a protein that is expressed in the skin and hair and its levels are regulated by various factors, including growth factors, Wnt signaling, and DNA damage. It is a potential drug target and has been shown to be involved in the development and progression of various skin and hair diseases, including cancer.

SKIC8 is involved in the regulation of cell growth and differentiation, and it is a key regulator of the formation of the hair follicle and the development of the hair matrix. It is also involved in the regulation of skin cell turned regeneration. Its levels are regulated by various factors, including growth factors, Wnt signaling, and DNA damage.

SKIC8 is a protein that is expressed in the skin and hair and it is known for its role in the development and maintenance of hair and skin. It is a member of the Ski complex and is involved in the regulation of various cellular processes, including cell growth, differentiation, and angiogenesis. It is a potential drug target and has been shown to be involved in the development and progression of various skin and hair diseases, including cancer.

SKIC8 is a protein that plays a key role in the regulation of cell growth and differentiation in the skin and hair. It is a member of the Ski complex and is involved in the formation of the hair follicle and the development of the hair matrix. It also plays a role in the regulation of skin cell turned regeneration. Its levels are regulated by various factors, including growth factors, Wnt signaling, and DNA damage.

SKIC8 is a protein that is expressed in the skin and hair and is known for its role in the development and maintenance of hair and skin. It is a member of the Ski complex and is involved in the regulation of various cellular processes, including cell growth, differentiation, and angiogenesis. It is a potential drug target and has been shown to be involved in the development and progression of various skin and hair diseases, including cancer.

SKIC8 is a protein that is expressed in the skin and hair and plays a key role in the regulation of cell growth and differentiation in the skin and hair. It is a member of the Ski complex and is involved in the formation of the hair follicle and the development of the hair matrix. It also plays a role in the regulation of skin cell turned regeneration. Its levels are regulated by various factors, including growth factors, Wnt signaling, and DNA damage.

SKIC8 is a protein that is expressed in the skin and hair and is known for its role in the development and maintenance of hair and skin. It is a member of the Ski complex and is involved in the regulation of various cellular processes, including cell growth, differentiation, and angiogenesis. It is a potential drug target and has been shown to be involved in the development and progression of various skin and hair diseases, including cancer.

SKIC8 is a protein that is expressed in the skin and hair and plays a key role in the regulation of cell

Protein Name: SKI8 Subunit Of Superkiller Complex

Functions: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (PubMed:16024656)

The "SKIC8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SKIC8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets