XKR4 Gene: Understanding Its Role in Blood Group Systems (G114786)

Target Name: XKR4

NCBI ID: G114786

XKR4

XKR4 Gene: Understanding Its Role in Blood Group Systems

The XKR4 gene, also known as X Kell blood group precursor-related family member 4, is a member of the X chromosome that plays a crucial role in the development and maintenance of blood group systems. Blood group systems are a group of genetic traits that are inherited from parents and are responsible for determining the antigens present on the surface of red blood cells. These antigens are part of the surface of the red blood cells and are able to react with specific antibodies that are present in the blood.

The XKR4 gene is responsible for the production of a protein known as XKL, which is a key component of the X chromosome. XKL plays a crucial role in the development and maintenance of the blood group system, as it helps to determine the specific antigens that are present on the surface of red blood cells.

Research has shown that changes in the levels of XKL in the body can be associated with a number of different health conditions, including cardiovascular disease, neurodegenerative diseases, and immune system-related disorders. Additionally, abnormal levels of XKL have been linked to certain diseases , such as sickle cell anemia and thalassemia.

As a result, the XKR4 gene has become a focus of interest for researchers studying the role of blood group genes in human health. Researchers are studying the XKR4 gene to better understand its role in the development and maintenance of blood group systems, as well as to identify potential drug targets or biomarkers for these diseases.

One potential drug target for XKR4 is the use of small molecules to modulate the levels of XKL in the body. This approach is being used to study the effects of these small molecules on the structure and function of the XKR4 gene, as well as their potential therapeutic benefits for blood group-related diseases.

Another potential biomarker for XKR4 is the use of genetic testing to identify individuals who are at risk for developing blood group-related diseases. This approach is being used to study the distribution of the XKR4 gene in the population and to identify genetic variations that may be associated with an increased risk of these diseases.

Overall, the XKR4 gene is a promising candidate for drug targeting and biomarker development for blood group-related diseases. Further research is needed to fully understand its role in the development and maintenance of blood group systems and to identify potential therapeutic approaches for these diseases.

Protein Name: XK Related 4

Functions: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987, PubMed:33725486)

The "XKR4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about XKR4 comprehensively, including but not limited to:
•   general information;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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