Target Name: RNF166
NCBI ID: G115992
Review Report on RNF166 Target / Biomarker Content of Review Report on RNF166 Target / Biomarker
RNF166
Other Name(s): RNF166 variant 1 | ring finger protein 166 | RN166_HUMAN | E3 ubiquitin-protein ligase RNF166 | RING finger protein 166 | Ring finger protein 166, transcript variant 1 | RING-type E3 ubiquitin transferase RNF166 | E3 ubiquitin-protein ligase RNF166 (isoform 1)

Overview of RNA-Nucleic Acid-Protein 166 (RNP166)

RNA-Nucleic Acid-Protein 166 (RNF166) is a gene that encodes a protein known as RNA-protein 166 (RNP166). RNP166 is a 22 kDa protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is involved in the regulation of cell growth, differentiation, and survival, and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the unique features of RNP166 is its ability to interact with other proteins, including the transcription factor NF-kappa-B. This interaction between RNP166 and NF-kappa-B has important implications for the regulation of gene expression and the development of diseases.

In addition to its role in cell signaling, RNP166 has also been shown to be a potential drug target. Several studies have identified RNP166 as a potential target for small molecule inhibitors, which could be used to treat a variety of diseases. For example, researchers have found that inhibiting RNP166 activity can lead to a reduction in the growth of cancer cells, and that this effect is dependent on NF-kappa-B signaling.

Another potential mechanism by which RNP166 may be targeted for drug intervention is its role in the development of neurodegenerative diseases. RNP166 has been shown to be involved in the regulation of neurotransmitter synthesis and release, and is therefore thought to be involved in the pathophysiology of a number of neurodegenerative diseases, including Alzheimer's and Parkinson's disease.

In addition to its potential as a drug target, RNP166 is also a promising biomarker for the diagnosis and monitoring of disease. Several studies have shown that RNP166 levels can be affected by a variety of factors, including neurodegenerative diseases, diabetes, and cancer. This makes RNP166 a potentially useful biomarker for the diagnosis and monitoring of these diseases.

Overall, RNP166 is a protein that has important roles in cell signaling and disease development. Its potential as a drug target and biomarker make it an attractive target for further research and development. Further studies are needed to fully understand the role of RNP166 in disease and to develop effective treatments.

Protein Name: Ring Finger Protein 166

Functions: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Also plays a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896)

The "RNF166 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF166 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1 | RNFT2 | RNGTT | RNH1 | RNLS | RNMT | RNPC3 | RNPC3-DT | RNPEP | RNPEPL1 | RNPS1 | RNPS1P1 | RNR1 | RNR2 | RNU1-1 | RNU1-100P | RNU1-108P | RNU1-11P | RNU1-134P | RNU1-18P | RNU1-3 | RNU1-31P | RNU1-32P | RNU1-36P | RNU1-38P | RNU1-4 | RNU1-42P | RNU1-55P | RNU1-61P | RNU1-63P | RNU1-72P | RNU1-73P | RNU1-78P | RNU1-7P | RNU1-82P | RNU1-88P | RNU105B | RNU11 | RNU12 | RNU2-1 | RNU2-17P | RNU2-2P | RNU2-4P | RNU2-54P | RNU2-5P