CLIC3: A Potential Drug Target and Biomarker (G9022)

Target Name: CLIC3

NCBI ID: G9022

CLIC3

CLIC3: A Potential Drug Target and Biomarker

CLIC3, short for trisomy Clyctosome, is a gene highly expressed in urine. The protein it encodes is a membrane protein that belongs to the CD28 superfamily and is mainly expressed on the surface of T cells and B cells. CLIC3 plays an important role in various immune responses and tumor growth. CLIC3 has become a subject of intense research interest due to its role in tumors and immune responses.

First, studies have shown that CLIC3 is expressed in a variety of tumor types, including lung cancer, breast cancer, renal cancer, and lymphoma. Unlike other tumor proteins, the expression of CLIC3 in tumor tissues is often higher than that in normal tissues. This suggests that CLIC3 may be a potential tumor therapeutic target.

Secondly, the expression level of CLIC3 is also related to the function of immune cells. Studies have shown that CLIC3 can serve as an indicator of the proliferation and activation of PD-1 positive T cells and PD-1 negative T cells. In addition, the expression level of CLIC3 is also related to the activity of CD8+ T cells, which provides clues for studying the role of CLIC3 in immune evasion.

Furthermore, studies have shown that CLIC3 is highly expressed in urine, which provides an opportunity to study the role of CLIC3 in kidney diseases. The detection of CLIC3 in urine is of great significance for assessing the degree of damage to the glomerular filtration membrane and the development of kidney disease.

In addition, CLIC3 has also been studied in relation to neurodegenerative diseases. Studies have shown that CLIC3 is associated with neuronal loss and reduced synapse number in neurodegenerative diseases. This provides a theoretical basis for studying the role of CLIC3 in the treatment of neurodegenerative diseases.

In summary, CLIC3 is a gene that plays an important role in tumors, immune responses, and neurodegenerative diseases. Through in-depth research on its expression level and function, it is expected to provide a basis for the development of CLIC3 as a drug target.

Protein Name: Chloride Intracellular Channel 3

Functions: Can insert into membranes and form chloride ion channels. May participate in cellular growth control

The "CLIC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLIC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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