CLIC4: A Role in Cell Division, Growth and Signal Transduction

Target Name: CLIC4

NCBI ID: G25932

CLIC4

CLIC4: A Role in Cell Division, Growth and Signal Transduction

CLIC4 (MTCLIC), a protein that belongs to the class of cytoskeletal proteins known as histamine receptors, is a protein that plays a crucial role in the regulation of cell division and growth. Mutations in the CLIC4 gene have been linked to various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

CLIC4 is a protein that is expressed in most tissues of the body and is involved in the regulation of cell division and growth. It is a member of the subfamily of G protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that play a key role in cellular signaling. GPCRs are characterized by the presence of a catalytic active site, a transmembrane region, and a cytoplasmic tail.

CLIC4 is involved in the regulation of cell division and growth by controlling the activity of several different signaling pathways. One of the well-established functions of CLIC4 is its role in the regulation of cell division. CLIC4 has been shown to play a role in the regulation of mitosis, meiosis, and cell division in various organisms, including bacteria and yeast.

Another function of CLIC4 is its role in the regulation of cell growth. CLIC4 has been shown to play a negative role in the regulation of cell growth by controlling the production of matrix associated proteins (MASPs), which are proteins that play a key role in the extracellular matrix (ECM) of cells. MASPs are involved in various cellular processes, including cell adhesion, migration, and invasion, and their production is regulated by various signaling pathways, including the TGF-β pathway.

CLIC4 is also involved in the regulation of cell survival and stress resistance. CLIC4 has been shown to play a role in the regulation of cell survival by controlling the production of stress-responsive proteins, such as heat shock proteins (HSPs) and DNA damage-repair proteins (DDRPs). HSPs are proteins that are involved in the regulation of various cellular processes, including stress response, DNA damage repair, and cytoskeletal organization. DDRPs are proteins that are involved in the regulation of DNA damage repair and are essential for the maintenance of cellular health.

In addition to its role in cell division, growth, and survival, CLIC4 is also involved in the regulation of cell signaling pathways. CLIC4 has been shown to play a role in the regulation of cell signaling pathways by controlling the activity of several different signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β pathway, and the Wnt signaling pathway.

GPCRs are a family of transmembrane proteins that play a key role in cellular signaling. They are characterized by the presence of a catalytic active site, a transmembrane region, and a cytoplasmic tail. CLIC4 is a member of the GPCR family and is involved in the regulation of cell division, growth, and survival. CLIC4 plays a crucial role in the regulation of cell signaling pathways and is a potential drug target for various diseases.

Protein Name: Chloride Intracellular Channel 4

Functions: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)

The "CLIC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLIC4 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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