WTIP: A Potential Drug Target and Biomarker (G126374)

Target Name: WTIP

NCBI ID: G126374

WTIP

Other Name(s): WT1 interacting protein | Wilms tumor 1 interacting protein | WT1-interacting protein | Wilms tumor protein 1-interacting protein | WTIP_HUMAN

WTIP: A Potential Drug Target and Biomarker

Welcome to this article on WTIP (WT1 interacting protein), a protein that has gained significant attention in recent years due to its potential as a drug target or biomarker. In this article, we will explore the structure, function, and potential clinical applications of WTIP, as well as its current status as a drug target and biomarker.

Structure and Function

WTIP is a 21-kDa protein that is expressed in various tissues, including the brain, heart, and kidneys. Its name is derived from WT1, a transcription factor that plays a crucial role in the development and maintenance of tissues, including the brain. WTIP is a highly conserved protein that shares 50% identity with WT1.

WTIP functions as a negative regulator of the transcription factor SMAD, which is involved in the regulation of gene expression. SMAD has been shown to play a role in the development and maintenance of various tissues, including the brain. Therefore, it is possible that WTIP may also be involved in the regulation of brain development and function.

WTIP has been shown to interact with various protein partners, including SMAD, T-COMT, and NF-kappa-B. These interactions are important for the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

Potential Clinical Applications

WTIP has the potential to be a drug target due to its involvement in the regulation of gene expression. Many diseases, including neurodegenerative disorders, are characterized by the disruption of normal gene expression. Therefore, targeting WTIP and its downstream targets may provide new therapeutic options for the treatment of these diseases.

WTIP has also been shown to be a potential biomarker for several diseases, including neurodegenerative disorders. The disruption of WTIP has been observed in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Therefore, measuring the levels of WTIP may be a useful diagnostic tool for the assessment of neurodegenerative disorders.

WTIP has also been shown to play a role in the regulation of inflammation. Chronic inflammation is a major risk factor for the development of various diseases, including neurodegenerative disorders. Therefore, targeting WTIP and its downstream targets may provide new therapeutic options for the treatment of chronic inflammation.

Current Status

WTIP is a well-established protein that has been studied extensively in the context of various diseases. Although several studies have demonstrated the potential of WTIP as a drug target and biomarker, more research is needed to fully understand its function and clinical applications.

In conclusion, WTIP is a protein that has gained significant attention in recent years due to its potential as a drug target or biomarker. Its structure and function have been well-studied, and its potential clinical applications are vast. Further research is needed to fully understand its function and determine its potential as a therapeutic option for the treatment of various diseases.

Protein Name: WT1 Interacting Protein

Functions: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity)

The "WTIP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WTIP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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