ADH5: A Potential Drug Target for Treating Alcohol-Related Diseases

Target Name: ADH5

NCBI ID: G128

ADH5

ADH5: A Potential Drug Target for Treating Alcohol-Related Diseases

Alcohol is a widely consumed beverage that has been linked to numerous health problems, including liver disease, certain cancers, and injuries. One of the enzymes that break down alcohol in the body is ADH5, which is a primary alcohol dehydrogenase enzyme located in the liver .ADH5 plays a crucial role in the metabolism of alcohol, breaking it down into toxic intermediates that can be eliminated from the body. However, ADH5 itself is also a potential drug target (or biomarker) because scientists have found that, By regulating the activity of ADH5, the metabolism and clearance of alcohol in the body can be affected.

ADH5 is an intracellular enzyme, and its encoding gene is ALDH5. ADH5 plays a wide range of roles in the liver and is a key enzyme in the alcohol metabolism pathway. In the liver, ADH5 catalyzes the oxidative dehydrogenation of alcohol, converting it into ethyl acetate. This reaction is the primary pathway for alcohol metabolism, so ADH5 plays a key role in controlling how long alcohol stays in the body.

In recent years, scientists have discovered an interesting phenomenon, that is, reducing ADH5 activity can increase the residence time of alcohol in the body. This discovery provides new ideas for studying the role of ADH5 in alcohol metabolism. In addition, scientists have also discovered that by regulating the activity of ADH5, the clearance rate of alcohol in the body can be affected. This discovery provides new ideas for studying the role of ADH5 in treating alcohol-related diseases.

ADH5 is a potential drug target (or biomarker). By regulating the activity of ADH5, the metabolism and clearance of alcohol in the body can be affected. This discovery provides new ideas for treating alcohol-related diseases.

Protein Name: Alcohol Dehydrogenase 5 (class III), Chi Polypeptide

Functions: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142)

The "ADH5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADH5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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