ADH7: A Potential Drug Target and Biomarker for Age-Related Decline

Target Name: ADH7

NCBI ID: G131

ADH7

ADH7: A Potential Drug Target and Biomarker for Age-Related Decline

Age-related decline is a natural part of human life, and it is characterized by a range of physiological changes that occur as the body accumulates damage over time. One of the key factors that contribute to this decline is the aging process, which is associated with the progressive loss of cells and the dysfunction of various biological systems. One of the proteins that has been linked to age-related decline is ADH7.

ADH7 (Adaptorin gene 7), also known as retinol dehydrogenase (RDH), is a gene that has been identified as a potential drug target and biomarker for age-related decline. The ADH7 gene is located on chromosome 18 and encodes a protein that is involved in the metabolism of retinol, a vitamin A derivative that is essential for vision and growth.

Retinol is a critical macromolecule that plays a vital role in the development and maintenance of skin and hair. It is a pro-hydrophobic molecule, which means that it has a tendency to stick to other molecules. This feature allows it to be easily absorbed into the skin and to be used for various therapeutic purposes. However, as the body ages, the ability of the skin to absorb retinol decreases, which can lead to various age-related conditions, including dry skin, fine lines, and wrinkles.

ADH7 has been linked to the dysfunction of various biological systems that are involved in the metabolism of retinol. For example, studies have shown that as the body ages, the levels of ADH7 in the skin decrease, which can lead to an increase in the levels of other molecules that can interact with retinol and cause damage. These molecules include reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to cellular components and contribute to various diseases, including aging.

In addition to its role in the metabolism of retinol, ADH7 has also been linked to the dysfunction of other biological systems that are involved in the aging process. For example, studies have shown that as the body ages, the levels of ADH7 in the brain decrease, which can lead to an increase in the levels of other molecules that can interact with retinol and cause damage. These molecules include ROS, which can cause damage to cellular components and contribute to the development of various age-related diseases, including Alzheimer's disease.

Despite the potential links between ADH7 and age-related decline, more research is needed to fully understand its role in this process. One of the key challenges in studying ADH7 is its expression and function in the body, as well as its potential as a drug target or biomarker.

In conclusion, ADH7 is a protein that has been linked to the aging process and various age-related conditions. Its role in the metabolism of retinol and its potential as a drug target or biomarker make it an attractive target for further research. Further studies are needed to fully understand its function in the aging process and its potential as a therapeutic intervention.

Protein Name: Alcohol Dehydrogenase 7 (class IV), Mu Or Sigma Polypeptide

Functions: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387)

The "ADH7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADH7 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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