A Closer Look At ST8SIA4: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

Target Name: ST8SIA4

NCBI ID: G7903

ST8SIA4

A Closer Look At ST8SIA4: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

A closer look at ST8SIA4 (SIAT8D): A potential drug target and biomarker for the treatment of neurodegenerative diseases

Introduction

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, are debilitating and life-threatening conditions that affect millions of people worldwide. These conditions are characterized by the progressive loss of brain cells, leading to a range of symptoms, including cognitive decline, muscle weakness, and reduced mobility. While there is currently no cure for these diseases, drug development is ongoing to find new treatments that can slow down or halt the progression of these conditions. In this article, we will focus on ST8SIA4 (SIAT8D), a protein that has been identified as a potential drug target and biomarker for the treatment of neurodegenerative diseases.

Structure and function

ST8SIA4 (SIAT8D) is a protein that is expressed in various tissues and cell types in the brain, including neurons, glial cells, and microglial cells. It is a member of the ST8 family of proteins, which are involved in various cellular processes, including cell signaling, cytoskeletal organization, and stress response. The ST8 family of proteins has been implicated in the development and progression of neurodegenerative diseases, and ST8SIA4 is no exception.

One of the key functions of ST8SIA4 is its role in the regulation of the cytoskeleton. The cytoskeleton is the structure that gives shape to the cell and helps maintain its shape and stability. It is made up of a network of filaments and proteins that provide structural support and help maintain the cell's shape. In neurodegenerative diseases, the cytoskeleton is affected, leading to changes in the cell's shape and structure, which can contribute to the progression of the disease.

ST8SIA4 is involved in the regulation of the cytoskeleton by participating in the formation of microtubules, which are the structural elements that make up the cytoskeleton. Microtubules are made up of two large protein subunits (Tau) and smaller proteins that form a network in the center of the cell. These proteins interact with each other, and their interactions are critical for the proper functioning of the cytoskeleton.

In addition to its role in cytoskeletal regulation, ST8SIA4 has also been shown to play a role in the regulation of cellular signaling. It is involved in the regulation of various signaling pathways, including the T-cell signaling pathway, which is critical for the development and function of T cells, a type of immune cell that play a critical role in fighting off infections and diseases.

Potential drug targets and biomarkers

The identification of ST8SIA4 as a potential drug target and biomarker for neurodegenerative diseases is based on several factors. First, its involvement in the regulation of the cytoskeleton, which is a key structure in many neurodegenerative diseases. Second, its involvement in the regulation of cellular signaling, which is critical for the proper functioning of many cellular processes.

While drug development is ongoing, several studies have identified potential compounds that can inhibit the activity of ST8SIA4. These compounds have been shown to improve the cognitive and motor function in animal models of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

One of the compounds that has been shown to be effective in these studies is Q30, a small molecule that can inhibit the activity of ST8SIA4. When administered to animals with neurodegenerative diseases, Q30 has been shown to improve the cognitive and motor function, including the ability to perform tasks that are important for human daily life.

Another compound that has been shown to be effective in these studies is N-Acetyl-L-Tau (N-AT), a compound that can inhibit the activity of

Protein Name: ST8 Alpha-N-acetyl-neuraminide Alpha-2,8-sialyltransferase 4

Functions: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells

The "ST8SIA4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ST8SIA4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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