WIPF2: A Potential Drug Target and Biomarker (G147179)
WIPF2: A Potential Drug Target and Biomarker
Wipf2, also known as Wiskott-Aldrich syndrome protein 2, is a protein that is expressed in the B cells of individuals with Wiskott-Aldrich syndrome (WAS). WAS is a rare autosomal recessive disorder that affects the development and function of B cells, which are responsible for producing antibodies to protect the body against infection.
Wipf2 is a key regulator of B cell development and function. It is expressed in the germinal center, which is the part of the bone marrow where B cells develop and mature. Wipf2 plays a role in the development of positive and negative selective B cells , which are the two types of B cells that are responsible for producing antibodies to protect the body against infection.
In individuals with WAS, the number of surface positive and negative selective B cells is usually very low. This is because the B cells in individuals with WAS are usually nonfunctional, and do not divide or produce antibodies. Wipf2 is thought to be responsible for regulating the number and function of these B cells.
Wipf2 is also involved in the regulation of inflammation. B cells are a key source of antibodies, which are proteins that help to protect the body against infection. When the body is exposed to an infection, the B cells in the immune system are activated and begin to divide and produce antibodies to fight the infection. Wipf2 is thought to be involved in the regulation of this process, and may help to ensure that the body produces the right amount of antibodies to fight off an infection.
In addition to its role in B cell development and function, Wipf2 is also thought to be involved in the regulation of stem cell proliferation. Stem cells are a type of cell that have the ability to develop into any type of cell in the body, and they are a key source of new cells that are used to replace damaged or cancerous cells. Wipf2 is thought to be involved in the regulation of stem cell proliferation, and may help to ensure that stem cells are produced in an optimal amount.
Wipf2 is also involved in the regulation of the immune response. The immune response is the body's ability to fight off infection and disease, and it is an essential part of the immune system. Wipf2 is thought to be involved in the regulation of the immune response. , and may help to ensure that the body has a strong and effective immune system.
In conclusion, Wipf2 is a protein that is expressed in the B cells of individuals with Wiskott-Aldrich syndrome. It is involved in the regulation of B cell development and function, inflammation, and stem cell proliferation. Wipf2 may also be involved in the regulation of the immune response. Because of its involvement in these processes, Wipf2 is thought to be a potential drug target and biomarker for the treatment of a variety of diseases.
Protein Name: WAS/WASL Interacting Protein Family Member 2
Functions: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system
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WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT | XAF1 | XAGE-4 | XAGE1A | XAGE1B | XAGE1D | XAGE2 | XAGE3 | XAGE5 | XBP1 | XCL1 | XCL2 | XCR1 | XDH | XG | XGY2 | XIAP | XIRP1 | XIRP2 | XIST | XK | XKR3 | XKR4 | XKR5 | XKR6 | XKR7 | XKR8 | XKR9 | XKRX | XKRY | XKRYP7 | XLOC_007697 | XLOC_008559 | XLOC_009911 | XNDC1N | XPA | XPC | XPC complex | XPNPEP1 | XPNPEP2 | XPNPEP3 | XPO1 | XPO4 | XPO5 | XPO6 | XPO7 | XPOT
