Target Name: WRAP73
NCBI ID: G49856
Review Report on WRAP73 Target / Biomarker Content of Review Report on WRAP73 Target / Biomarker
WRAP73
Other Name(s): FLJ20430 | WD repeat domain 8 protein | WD repeat-containing protein antisense to TP73 | WD repeat-containing protein antisense to TP73 gene | WD repeat containing, antisense to TP73 | WDR8 | OTTHUMP00000000664 | MGC99569 | OTTHUMP00000000666 | WRP73_HUMAN | OTTHUMP00000000665 | epididymis secretory sperm binding protein | WD repeat-containing protein WRAP73 | WD repeat domain 8 | WD repeat-containing protein 8

Understanding WRAP73: A Potential Drug Target and Biomarker

WRAP73 (FLJ20430) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the WRAP family of proteins, which are known for their role in the regulation of cell proliferation and differentiation.

WRAP73 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its function as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments.

One of the key features of WRAP73 is its ability to interact with various signaling pathways. It has been shown to play a role in the signals transduction pathways that regulate cell proliferation, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development of many diseases.

In addition to its role in cell signaling, WRAP73 has also been shown to play a role in the regulation of cellular processes that are important for maintaining tissue homeostasis. This includes the regulation of cell volume, cell-cell adhesion, and the regulation of ion and water balance.

As a drug target, WRAP73 is of particular interest to researchers because of its potential to intervene in a wide range of diseases. Its role in the regulation of cell proliferation and differentiation makes it a potential target for cancer therapies. Its ability to interact with various Signaling pathways also makes it a potential target for drugs that target neurodegenerative diseases.

In addition to its potential as a drug target, WRAP73 has also been shown to be a potential biomarker for a number of diseases. Its expression has been shown to be elevated in a variety of cancer types, including breast, ovarian, and colorectal cancers. This suggests that it may be a useful indicator of disease status in these cases.

Furthermore, WRAP73 has also been shown to play a role in the regulation of cellular processes that are important for maintaining tissue homeostasis. This includes the regulation of cell volume, cell-cell adhesion, and the regulation of ion and water balance. This suggests that it may be a useful target for drugs that aim to restore cellular homeostasis in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, WRAP73 is a protein that has been shown to play a role in the regulation of various cellular processes that are important for maintaining tissue homeostasis. Its potential as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for a wide range of diseases. Further research is needed to fully understand its role and potential as a drug target and biomarker.

Protein Name: WD Repeat Containing, Antisense To TP73

Functions: The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238)

The "WRAP73 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WRAP73 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT | XAF1 | XAGE-4 | XAGE1A | XAGE1B | XAGE1D | XAGE2 | XAGE3 | XAGE5 | XBP1 | XCL1 | XCL2 | XCR1 | XDH | XG | XGY2 | XIAP | XIRP1 | XIRP2 | XIST | XK | XKR3 | XKR4 | XKR5 | XKR6 | XKR7 | XKR8 | XKR9 | XKRX | XKRY | XKRYP7 | XLOC_007697 | XLOC_008559 | XLOC_009911 | XNDC1N | XPA | XPC | XPC complex | XPNPEP1 | XPNPEP2 | XPNPEP3 | XPO1 | XPO4 | XPO5 | XPO6 | XPO7 | XPOT | XPR1 | XRCC1 | XRCC2 | XRCC3 | XRCC4 | XRCC5 | XRCC6 | XRCC6P5 | XRN1 | XRN2 | XRRA1 | XXYLT1 | XXYLT1-AS2 | XYLB | XYLT1 | XYLT2 | YAE1 | YAF2 | YAP1 | YARS1 | YARS2 | YBEY | YBX1 | YBX1P1 | YBX1P10 | YBX1P2 | YBX1P4 | YBX2 | YBX3 | YBX3P1 | YDJC