Target Name: WRN
NCBI ID: G7486
Review Report on WRN Target / Biomarker Content of Review Report on WRN Target / Biomarker
WRN
Other Name(s): RecQ3 | RECQL2 | RECQL3 | DNA helicase, RecQ-like type 3 | Werner Syndrome helicase | Werner syndrome RecQ like helicase | recQ protein-like 2 | Bifunctional 3'-5' exonuclease/ATP-dependent helicase W

Study of WRN's Role in Neural Stem Cell Development and Maintenance

WRN (Wiskott-Aldrich Neuron) is a protein that is expressed in the nervous system and plays a crucial role in the development and maintenance of the nervous system. It is a transmembrane protein that is composed of four transmembrane domains and a cytoplasmic tail. WRN is involved in a wide range of physiological processes in the nervous system, including cell signaling, neurotransmitter release, and inflammation.

One of the functions of WRN is its role in the development and maintenance of the cerebral cortical neural stem cells. These stem cells are responsible for the formation and maintenance of the cerebral cortex, which is the outer layer of the brain and is responsible for many of the higher cognitive functions. During development, the neural stem cells in the cerebral cortex migrate from the brainstem to the cortical floor, where they differentiate into neurons and form the cerebral cortical neural stem cell niche.

Another function of WRN is its role in the regulation of neurotransmitter release. neurotransmitters are chemical messengers that are used by the nervous system to communicate with other cells and to regulate various physiological processes. WRN is involved in the release of several neurotransmitters, including dopamine, serotonin, and nitric oxide. These neurotransmitters play a crucial role in the transmission of signals in the nervous system and are involved in a wide range of physiological processes, including mood regulation, appetite, and pain perception.

WRN is also involved in the regulation of inflammation in the nervous system. It is has been shown to play a role in the regulation of immune cell function and the production of pro-inflammatory cytokines. These cytokines can contribute to the inflammatory response of the nervous system and can be involved in the development of neurodegenerative diseases.

In addition to its role in the development and maintenance of neural stem cells and the regulation of neurotransmitter release, WRN is also involved in the regulation of cell survival. It is a pro-survival protein that can prevent the programmed cell death that occurs in response to various cellular stressors, such as oxidative stress, UV radiation, and chemotherapy.

Despite the many important functions of WRN, it is not yet clear what the ultimate drug target or biomarker for this protein may be. Many researchers are interested in the potential of drugs that can modulate the activity of WRN in order to treat various neurological and psychiatric disorders.

One approach to identifying potential drug targets for WRN is to study its downstream signaling pathways. These pathways are the chemical reactions that occur after the protein is translated from the mRNA, and they can provide valuable information about the functions of the protein.

One of the downstream signaling pathways that is being studied in relation to WRN is the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular survival and growth, and it is thought to be involved in the development of neurodegenerative diseases. Several studies have shown that WRN can modulate the activity of the PI3K/Akt signaling pathway, and that this modulation is involved in the regulation of neural stem cell survival.

Another potential drug target for WRN is the neurotransmitter systems. As previously mentioned, WRN is involved in the regulation of neurotransmitter release, and it is thought to play a role in the development of neurotransmitter disorders. Several studies have shown that drugs that can modulate neurotransmitter release can be effective in treating various psychiatric and neurological disorders, including depression, anxiety, and schizophrenia.

Another approach to identifying potential drug targets for WRN is to study its role in the development and maintenance of the cerebral cortical neural stem cells. As previously mentioned, WRN is involved in the development and maintenance of these stem cells, and it is thought to play a role in the development of neurodegenerative diseases. Several studies have shown that drugs that can modulate the stem cell niche, such as those that can

Protein Name: WRN RecQ Like Helicase

Functions: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation

The "WRN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WRN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT | XAF1 | XAGE-4 | XAGE1A | XAGE1B | XAGE1D | XAGE2 | XAGE3 | XAGE5 | XBP1 | XCL1 | XCL2 | XCR1 | XDH | XG | XGY2 | XIAP | XIRP1 | XIRP2 | XIST | XK | XKR3 | XKR4 | XKR5 | XKR6 | XKR7 | XKR8 | XKR9 | XKRX | XKRY | XKRYP7 | XLOC_007697 | XLOC_008559 | XLOC_009911 | XNDC1N | XPA | XPC | XPC complex | XPNPEP1 | XPNPEP2 | XPNPEP3 | XPO1 | XPO4 | XPO5 | XPO6 | XPO7 | XPOT | XPR1 | XRCC1 | XRCC2 | XRCC3 | XRCC4 | XRCC5 | XRCC6 | XRCC6P5 | XRN1 | XRN2 | XRRA1 | XXYLT1 | XXYLT1-AS2 | XYLB | XYLT1 | XYLT2 | YAE1 | YAF2 | YAP1 | YARS1 | YARS2 | YBEY | YBX1 | YBX1P1 | YBX1P10 | YBX1P2 | YBX1P4 | YBX2 | YBX3 | YBX3P1 | YDJC | YEATS2