Target Name: FITM1
NCBI ID: G161247
Review Report on FITM1 Target / Biomarker Content of Review Report on FITM1 Target / Biomarker
FITM1
Other Name(s): fat storage-inducing transmembrane protein 1 | FITM1_HUMAN | fat-inducing transcript 1 | Fat storage inducing transmembrane protein 1 | Fat-inducing protein 1 | fat-inducing protein 1 | FIT1 | fat storage inducing transmembrane protein 1 | Fat storage-inducing transmembrane protein 1

Introduction to FITM1
FITM1 (Fatty Acid Transporter, Mitochondrial 1) is a protein that plays a crucial role in fatty acid metabolism and transport. It is considered a significant drug target and a potential biomarker for various metabolic disorders. In this article, we will explore the function, structure, and therapeutic implications of FITM1.

The Role of FITM1 in Fatty Acid Metabolism:
FITM1 is primarily located in the mitochondria and is responsible for the transport of fatty acids into this cellular organelle. It acts as a gatekeeper, ensuring a balanced supply of fatty acids is available for 尾-oxidation, a vital process for generating energy in the form of ATP. This energy generation is particularly crucial in tissues with high energy demands, such as the heart, liver, and skeletal muscles.

Moreover, FITM1 also assists in maintaining cellular lipid homeostasis by regulating the partitioning of fatty acids between storage and oxidation. It does so by incorporating fatty acids into lipid droplets or facilitating their transport out of lipid droplets for utilization as an energy source. Dysregulation of FITM1 function can disrupt these processes, leading to the development of metabolic disorders such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).

The Structure of FITM1:
FITM1 is a transmembrane protein consisting of six alpha-helical transmembrane domains. These domains allow FITM1 to span the mitochondrial membrane, providing a conduit for fatty acid transport. The protein's structure also includes cytosolic regions, which are believed to be involved in protein-protein interactions and regulation of its activity.

Therapeutic Implications:
Due to its critical role in fatty acid metabolism and its association with metabolic disorders, FITM1 has emerged as a promising drug target. Developing pharmacological agents that modulate FITM1 activity could potentially alleviate metabolic abnormalities and improve overall health outcomes.

One potential approach is to design drugs that increase FITM1 expression or activity. By enhancing fatty acid uptake and oxidation, these drugs could promote weight loss, improve insulin sensitivity, and reduce the accumulation of fatty acids in the liver. Additionally, stimulating FITM1 function may help attenuate oxidative stress, which is often associated with metabolic dysfunction.

Conversely, inhibiting FITM1 activity could be beneficial in specific contexts. For instance, in certain cancer cells that rely on increased lipid metabolism for survival and proliferation, blocking FITM1-mediated fatty acid transport could hinder their growth. Targeting FITM1 may also have implications in neurodegenerative diseases, as disrupted fatty acid metabolism is commonly observed in conditions like Alzheimer's and Parkinson's.

FITM1 as a Biomarker:
In addition to being a drug target, FITM1 shows promise as a biomarker for metabolic disorders. Several studies have reported alterations in FITM1 expression levels in individuals affected by obesity, insulin resistance, and NAFLD. These findings suggest the potential use of FITM1 as a diagnostic tool to identify individuals at risk or monitor disease progression.

Furthermore, FITM1 may also serve as a predictive biomarker for drug response. Variations in FITM1 expression or genetic mutations in the FITM1 gene may influence an individual's susceptibility to certain pharmacological therapies targeting metabolic disorders. By identifying such variations, personalized medicine approaches can be developed to optimize treatment strategies and improve patient outcomes.

Conclusion:
FITM1, a key player in fatty acid metabolism and transport, holds significant potential as a drug target and biomarker. Understanding its role in maintaining metabolic homeostasis and developing pharmacological agents that modulate FITM1 function could offer novel therapeutic strategies for metabolic disorders. Moreover, utilizing FITM1 as a diagnostic and predictive biomarker may enable early detection and personalized treatment approaches, ultimately benefiting patient care and public health.

Protein Name: Fat Storage Inducing Transmembrane Protein 1

Functions: Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity)

The "FITM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FITM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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