FMO3: A Potential Drug Target for Many Diseases (G2328)

Target Name: FMO3

NCBI ID: G2328

FMO3

FMO3: A Potential Drug Target for Many Diseases

Hepatic flavin-containing monooxygenase 3 (FMO3) is a protein that is expressed in the liver and is involved in the metabolism of flavins, which are a group of pigments that are found in red and yellow fruits and vegetables. Flavins are important for many different functions in the body, including the regulation of inflammation and the detoxification of harmful substances.

FMO3 is a monooxygenase, which means that it is able to catalyze the breakdown of a molecule into two smaller molecules. In the case of FMO3, this breakdown occurs in the liver, where it helps to remove harmful substances that have been formed during the metabolism of flavins.

One of the key functions of FMO3 is its role in the detoxification of polycyclic aromatic hydrocarbons (PAHs). PAHs are often found in environmental and industrial settings and have been linked to a variety of health problems, including cancer and liver disease. FMO3 has been shown to be able to significantly reduce the levels of PAHs in the liver, which can help to protect against these harmful substances.

Another important function of FMO3 is its role in the regulation of inflammation. Many different types of inflammation in the body can be harmful, and it is important for the immune system to respond to and control these inflammasins. FMO3 has been shown to be involved in the regulation of inflammasins, which can help to prevent excessive or chronic inflammation.

In addition to its role in the detoxification of harmful substances and the regulation of inflammation, FMO3 is also a potential drug target. Because it is involved in the metabolism of many different compounds, it is a potential target for small molecules that can be used to inhibit its activity. This could be useful for the development of new treatments for a variety of diseases, including cancer, liver disease, and inflammatory disorders.

Overall, FMO3 is a protein that is involved in many important functions in the body. Its potential as a drug target makes it an attractive target for researchers to explore for new treatments. Further research is needed to fully understand the role of FMO3 in the body and its potential as a drug.

Protein Name: Flavin Containing Dimethylaniline Monoxygenase 3

Functions: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269)

The "FMO3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FMO3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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