Target Name: FKBP1A
NCBI ID: G2280
Review Report on FKBP1A Target / Biomarker Content of Review Report on FKBP1A Target / Biomarker
FKBP1A
Other Name(s): FKBP prolyl isomerase 1A | FKBP1A variant 1 | protein kinase C inhibitor 2 | FKBP1 | Rotamase | FK506-binding protein 12 | FKB1A_HUMAN | immunophilin FKBP12 | rotamase | Rotamase (FKBP12) | 12 kDa FKBP | FKBP12C | FK506 binding protein 1A, 12kDa | FKBP prolyl isomerase 1A, transcript variant 1 | FKBP-12 | calstabin-1 | Peptidyl-prolyl cis-trans isomerase FKBP1A (isoform a) | Protein kinase C inhibitor 2 | FK506 binding protein12 | FKBP12-Exip3 | FKBP12 | FK506-binding protein, T-cell, 12-kD | Immunophilin FKBP12 | Calstabin-1 | FK506-binding protein 1 | FK506-binding protein 1A (12kD) | 12 kDa FK506-binding protein | Peptidyl-prolyl cis-trans isomerase FKBP1A | PPIase FKBP1A | FK506-binding protein 1A | PPIASE | PKC12 | PKCI2 | FKBP-1A | 12B

FKBP1A: A Potential Drug Target and Biomarker

Protein folding is a critical process that occurs in all living organisms, and it is during this process that misfolded proteins can contribute to a wide range of cellular and societal issues, including diseases such as Alzheimer's, Parkinson's, and various cancers. One of the proteins Involved in protein folding is FKBP1A, which is a key regulator of the folding process and has been identified as a potential drug target and biomarker.

FKBP1A, also known as prolyl isomerase 1A, is a protein that is expressed in most tissues of the body and is involved in the regulation of protein folding. It is a 21-kDa protein that consists of 21 amino acid residues and has a calculated pI of 9.6. FKBP1A is highly conserved across various species, which suggests that it has been evolutionarily conserved for a long time.

FKBP1A plays a crucial role in the regulation of protein folding by interacting with several different protein partners, including other proteins that are involved in the folding process, such as the heat shock protein (HSP) complex. It is well established that misfolded proteins can cause a wide range of cellular and societal issues, including the development of diseases such as Alzheimer's, Parkinson's, and various cancers. FKBP1A has been shown to play a key role in the regulation of protein folding and has been identified as a potential drug target.

One of the key functions of FKBP1A is its ability to interact with HSPs, which are proteins that are involved in the folding process. HSPs are able to bind to FKBP1A and prevent it from forming a covalent complex with other proteins, which would otherwise prevent the protein from being correctly folded. This interaction between FKBP1A and HSPs allows the protein to undergo a process of post-translational modification, which is the process by which the protein is modified after its synthesis but before it is translated into an functional protein.

FKBP1A has been shown to play a key role in the regulation of protein folding by interacting with HSPs. It is well established that misfolded proteins can cause a wide range of cellular and societal issues, including the development of diseases such as Alzheimer's, Parkinson's, and various cancers. FKBP1A has been shown to play a key role in the regulation of protein folding and has been identified as a potential drug target.

In addition to its role in the regulation of protein folding, FKBP1A has also been shown to play a key role in the regulation of protein stability and cell survival. It is well established that misfolded proteins can contribute to the development of various diseases, including cancer . FKBP1A has been shown to play a key role in the regulation of protein stability and cell survival by interacting with the protein BCL-2. BCL-2 is a protein that has been shown to play a key role in the regulation of cell growth and apoptosis, and it is thought to contribute to the development of various diseases, including cancer.

FKBP1A has also been shown to play a key role in the regulation of protein translation, which is the process by which the RNA molecule is translated into a functional protein. It is well established that misfolded proteins can contribute to the development of various diseases, including cancer. FKBP1A has been shown to play a key role in the regulation of protein translation by interacting with the protein known asTranslin. Translin is a protein that is involved in

Protein Name: FKBP Prolyl Isomerase 1A

Functions: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

The "FKBP1A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FKBP1A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

FKBP1A-SDCBP2 | FKBP1B | FKBP1C | FKBP2 | FKBP3 | FKBP4 | FKBP5 | FKBP6 | FKBP7 | FKBP8 | FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3 | FMO4 | FMO5 | FMO6P | FMO9P | FMOD | FMR1 | FMR1-AS1 | FMR1NB | FN1 | FN3K | FN3KRP | FNBP1 | FNBP1L | FNBP1P1 | FNBP4 | FNDC1 | FNDC10 | FNDC11 | FNDC3A | FNDC3B | FNDC4 | FNDC5 | FNDC7