Target Name: FKBP8
NCBI ID: G23770
Review Report on FKBP8 Target / Biomarker Content of Review Report on FKBP8 Target / Biomarker
FKBP8
Other Name(s): FKBP prolyl isomerase 8 | Peptidyl-prolyl cis-trans isomerase FKBP8 | Rotamase | FK506-binding protein 8 (38kD) | Peptidyl-prolyl cis-trans isomerase FKBP8 (isoform 1) | FKBPR38 | FKBP8_HUMAN | rotamase | FK506-binding protein 8 | FK506 binding protein 8, 38kDa | FKBPr38 | hFKBP38 | FK506 binding protein 8 | FKBP prolyl isomerase 8, transcript variant 1 | PPIase FKBP8 | FK506 binding protein 8 (38kD) | FKBP38 | FKBP-8 | 38 kDa FK506-binding protein | FKBP8 variant 1 | 38 kDa FKBP | FKBP-38

FKBP8: A Potential Drug Target and Biomarker

Proteins play a crucial role in almost every cellular process in the human body. Among the various proteins that contribute to protein homeostasis, the FKBP8 protein is an essential enzyme for the regulation of protein synthesis and degradation. FKBP8 is a 26-kDa protein that belongs to the superfamily of cup protein. It is expressed in most tissues and cells and is involved in various cellular processes, including cell signaling, protein homeostasis, and inflammation.

In recent years, researchers have discovered that FKBP8 is involved in a wide range of physiological processes, including cell signaling, DNA replication, and stress resistance. Moreover, several studies have identified potential drug targets in FKBP8, suggesting that this protein may be a valuable drug target for the development of new therapeutic approaches.

Drug Targets

1. FKBP8 Inhibitors

One of the primary drug targets associated with FKBP8 is the inhibition of FKBP8-mediated protein synthesis and degradation. This is achieved by either inhibiting the activity of FKBP8 itself or by preventing the binding of FKBP8 to its downstream targets, such as the protein FKBP12.

In recent years, several studies have reported the synthesis and characterization of various inhibitors of FKBP8, including small molecules, peptides, and antibodies. These inhibitors have been shown to interfere with FKBP8-mediated protein synthesis and degradation, leading to the inhibition of cellular processes , including cell signaling, DNA replication, and stress resistance.

2. FKBP8 Activators

Another potential drug target associated with FKBP8 is the activation of FKBP8-mediated protein synthesis and degradation. This is achieved by either increasing the activity of FKBP8 or by enhancing its interaction with its downstream targets, such as the protein FKBP12.

Several studies have reported the synthesis and characterization of various activators of FKBP8, including small molecules, peptides, and antibodies. These activators have been shown to increase the activity of FKBP8, leading to the stimulation of cellular processes, including cell signaling, DNA replication, and stress resistance.

3. FKBP8 Antibodies

Another potential drug target associated with FKBP8 is the production of antibodies that recognize and interact with FKBP8. These antibodies can be used to study the FKBP8-mediated signaling pathways and to identify new drug targets.

Several studies have reported the synthesis and characterization of antibodies that recognize and interact with FKBP8. These antibodies have been shown to recognize and bind to FKBP8, leading to the inhibition of FKBP8-mediated protein synthesis and degradation.

Biomarkers

1. FKBP8 Levels

The levels of FKBP8 in cells can be used as a biomarker for the assessment of FKBP8 activity and efficacy of FKBP8-mediated drugs. Several studies have reported the quantification of FKBP8 levels in various cellular contexts, including cell extracts, tissues, and cells. These. levels can be used to monitor the efficacy of FKBP8-mediated drugs and to identify potential biomarkers for FKBP8-mediated signaling pathways.

2. FKBP8 Expression

The expression of FKBP8 can be used as a biomarker for the assessment of FKBP8 activity and potential drug targets. Several studies have reported the quantification of FKBP8 expression in various cellular contexts, including cell extracts, tissues, and cells. These levels can be used to monitor the efficacy of FKBP8-mediated drugs and to identify potential biomarkers for FKBP8-mediated signaling pathways.

3. FKBP8 Interaction

The interaction of FKBP8 with its downstream targets, such as the protein FKBP12, can be used as a biomarker for the assessment of FKBP8 activity and potential drug targets. Several studies have reported the quantification of FKBP8-FKBP12 interactions, including in vitro and in vivo experiments. These levels can be used to monitor the efficacy of FKBP8-mediated drugs and to identify potential biomarkers for FKBP8-mediated signaling pathways.

Conclusion

In conclusion, FKBP8 is a protein that plays a crucial role in various cellular processes, including cell signaling, protein homeostasis, and stress resistance. Its role in these processes makes FKBP8 an attractive drug target for the development of new therapeutic approaches. Several studies have identified potential drug targets in FKBP8, including inhibitors and activators of FKBP8-mediated protein synthesis and degradation, and antibodies that recognize and interact with FKBP8. Additionally, the levels of FKBP8 and its interaction with its downstream targets can be used as biomarkers for the assessment of FKBP8 activity and potential drug targets. Further research is needed to fully understand the role of FKBP8 in cellular processes and to develop new therapeutic approaches based on FKBP8 as a drug target.

Protein Name: FKBP Prolyl Isomerase 8

Functions: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297)

The "FKBP8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FKBP8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3 | FMO4 | FMO5 | FMO6P | FMO9P | FMOD | FMR1 | FMR1-AS1 | FMR1NB | FN1 | FN3K | FN3KRP | FNBP1 | FNBP1L | FNBP1P1 | FNBP4 | FNDC1 | FNDC10 | FNDC11 | FNDC3A | FNDC3B | FNDC4 | FNDC5 | FNDC7 | FNDC8 | FNDC9 | FNIP1 | FNIP2 | FNTA | FNTB | FOCAD | Focal Adhesion Kinases (FAK) | Folate Receptor | FOLH1