FLT1: A Potential Drug Target (G2321)

Target Name: FLT1

NCBI ID: G2321

FLT1

FLT1: A Potential Drug Target

FLT1 (Fms-like tyrosine kinase 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the Fms family of tyrosine kinases, which are known for their ability to induce programmed cell death, also known as apoptosis.

FLT1 is involved in many different cellular processes in the body, including cell signaling, neurotransmitter release, and stress response. It is also involved in the development and progression of various diseases, including cancer.

One of the things that makes FLT1 such a promising drug target is its involvement in cell signaling. FLT1 has been shown to play a role in the regulation of cell proliferation, and it is thought to be involved in the control of cell lifespan. This makes it a potential target for drugs that are designed to inhibit cell proliferation or extend lifespan.

Another potential mechanism by which FLT1 may be targeted by drugs is its role in neurotransmitter release. FLT1 is known to be involved in the release of various neurotransmitters, including neurotransmitters that are involved in pain signaling and mood regulation. This makes it a potential target for drugs that are designed to modulate neurotransmitter release.

FLT1 is also involved in many different stress responses, including the regulation of inflammation and stress-induced cellular death. This makes it a potential target for drugs that are designed to modulate stress responses and protect against cellular stress.

Despite its many functions in the body, FLT1 is also a potential drug target because of its involvement in the development and progression of various diseases. For example, FLT1 has been shown to be involved in the development of cancer, and it is also thought to be involved in the regulation of aging. This makes it a potential target for drugs that are designed to inhibit cancer development or promote cellular aging.

In conclusion, FLT1 is a protein that is involved in many different cellular processes throughout the body. It is a potential drug target due to its involvement in cell signaling, neurotransmitter release, stress response, and cancer development. Further research is needed to fully understand the role of FLT1 in the body and to identify potential drugs that can target it.

Protein Name: Fms Related Receptor Tyrosine Kinase 1

Functions: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275)

The "FLT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FLT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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