Target Name: EIF5A
NCBI ID: G1984
Review Report on EIF5A Target / Biomarker Content of Review Report on EIF5A Target / Biomarker
EIF5A
Other Name(s): IF5A1_HUMAN | rev-binding factor | EIF-5A-1 | eukaryotic initiation factor 5A | Eukaryotic translation initiation factor 5A, transcript variant A | eukaryotic translation initiation factor 5A | OTTHUMP00000128384 | EIF5A variant B | eIF5AI | EIF-5A | eIF-4D | Eukaryotic translation initiation factor 5A (eIF-5A) | Eukaryotic initiation factor 5A | EIF-5A1 | EIF5A variant A | MGC104255 | FABAS | eIF-5A | Eukaryotic translation initiation factor 5A-1 (isoform A) | EIF-4D | MGC99547 | EIF5AI | eIF-5A1 | eIF-5A-1 | Eukaryotic translation initiation factor 5A, transcript variant B | Eukaryotic translation initiation factor 5A-1 | Eukaryotic translation initiation factor 5A-1 (isoform B) | Rev-binding factor | Eukaryotic initiation factor 5A isoform 1 | EIF5A1

EIF5A: A Potential Drug Target and Biomarker

EIF5A, short for Enhanced Interleukin-8 Release (EIR), is a protein that is expressed in various tissues and cells throughout the body. It is a key player in the immune response and has been implicated in a number of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

One of the key functions of EIF5A is its role in the production of interleukin-8 (IL-8), a cytokine that plays a crucial role in the immune response and has been linked to a number of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. IL-8 has been shown to promote the growth and survival of cancer cells and has been used as a potential therapeutic target in a number of studies.

In addition to its role in IL-8 production, EIF5A has also been shown to play a number of other roles in the immune response. For example, it has been shown to regulate the production of antibodies by B cells, which are critical for the immune response. It has also been shown to play a role in the regulation of T cell activity, which is critical for the immune response.

Given the number of roles that EIF5A has been shown to play in the immune response, it is a potential drug target that could be targeted with small molecules or antibodies. Studies have shown that inhibiting EIF5A can lead to a number of benefits, including the inhibition of cancer cell growth and the regulation of autoimmune disorders.

In addition to its potential as a drug target, EIF5A is also a potential biomarker for a number of diseases. The production of IL-8 by EIF5A has been shown to be elevated in a number of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. This suggests that EIF5A may be a useful biomarker for these diseases and could be used to diagnose and monitor the progress of these conditions.

Overall, EIF5A is a protein that has the potential to be a drug target and biomarker for a number of diseases. Further research is needed to fully understand its role in the immune response and to develop effective treatments for diseases that are caused by its overproduction or dysfunction.

Protein Name: Eukaryotic Translation Initiation Factor 5A

Functions: mRNA-binding protein involved in translation elongation (PubMed:16987817, PubMed:17187778, PubMed:33547280). Has an important function at the level of mRNA turnover, probably acting downstream of decapping (PubMed:16987817, PubMed:17187778, PubMed:33547280). Critical for the efficient synthesis of peptide bonds between consecutive proline residues (PubMed:16987817, PubMed:17187778, PubMed:33547280). Can resolve ribosomal stalling caused by consecutive prolines during translation (PubMed:16987817, PubMed:17187778, PubMed:33547280). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817, PubMed:17187778, PubMed:33547280). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Regulates also TNF-alpha-mediated apoptosis (PubMed:15452064). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts (PubMed:8253832)

The "EIF5A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF5A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

EIF5A2 | EIF5AL1 | EIF5B | EIF6 | EIPR1 | ELAC1 | ELAC2 | ELANE | ELAPOR1 | ELAPOR2 | Elastase | ELAVL1 | ELAVL2 | ELAVL3 | ELAVL4 | ELDR | ELF1 | ELF2 | ELF2P4 | ELF3 | ELF3-AS1 | ELF4 | ELF5 | ELFN1 | ELFN1-AS1 | ELFN2 | ELK1 | ELK2AP | ELK3 | ELK4 | ELL | ELL2 | ELL2P1 | ELL3 | ELMO1 | ELMO2 | ELMO3 | ELMOD1 | ELMOD2 | ELMOD3 | ELN | ELOA | ELOA-AS1 | ELOA2 | ELOA3BP | ELOA3DP | ELOA3P | ELOB | ELOC | ELOF1 | Elongation Factor 1 Complex | Elongation of very long chain fatty acids protein | Elongin (SIII) complex | ELOVL1 | ELOVL2 | ELOVL2-AS1 | ELOVL3 | ELOVL4 | ELOVL5 | ELOVL6 | ELOVL7 | ELP1 | ELP2 | ELP3 | ELP4 | ELP5 | ELP6 | ELSPBP1 | EMB | EMBP1 | EMC1 | EMC1-AS1 | EMC10 | EMC2 | EMC3 | EMC3-AS1 | EMC4 | EMC6 | EMC7 | EMC8 | EMC9 | EMCN | EMD | EME1 | EME2 | EMG1 | EMID1 | EMILIN1 | EMILIN2 | EML1 | EML2 | EML2-AS1 | EML3 | EML4 | EML4-AS1 | EML5 | EML6 | EMP1 | EMP2 | EMP2P1