EMC1: A Protein Targeted for Therapeutic Use in Multiple Diseases

Target Name: EMC1

NCBI ID: G23065

EMC1

EMC1: A Protein Targeted for Therapeutic Use in Multiple Diseases

EMC1 (KIAA0090) is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and kidneys. It is a member of the IMP family of proteins, which are involved in the regulation of implantation and inflammation.

EMC1 has been shown to play a role in several important physiological processes in the body, including the regulation of inflammation and inflammation-induced pain. It has also been shown to be involved in the development and progression of several diseases, including cancer.

As a potential drug target, EMC1 is being studied for its potential therapeutic uses in a variety of conditions, including cancer, autoimmune diseases, and neurodegenerative diseases.

One of the main reasons for the interest in EMC1 is its ability to interact with several different signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. The TGF-β pathway is involved in the regulation of cell growth, differentiation, and inflammation, while the NF-kappa-B pathway is involved in the regulation of inflammation and pain.

EMC1 has been shown to play a role in the regulation of TGF-β signaling in several tissues. For example, studies have shown that EMC1 can inhibit the activity of the TGF-β receptor, which is involved in the regulation of cell growth and differentiation. This can lead to the suppression of TGF-β signaling, which can have negative effects on the growth and development of cancer cells.

EMC1 has also been shown to play a role in the regulation of NF-kappa-B signaling in several tissues. For example, studies have shown that EMC1 can inhibit the activity of the NF-kappa-B receptor, which is involved in the regulation of inflammation and pain. This can lead to the suppression of NF-kappa-B signaling, which can have negative effects on the development and progression of inflammatory diseases.

In addition to its role in the regulation of signaling pathways, EMC1 is also being studied for its potential therapeutic uses in a variety of diseases. For example, studies have shown that EMC1 may be involved in the development and progression of cancer, including breast cancer. Additionally, EMC1 has been shown to be involved in the development and progression of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis.

Overall, EMC1 is a protein that is being studied for its potential therapeutic uses in a variety of diseases. Its ability to interact with multiple different signaling pathways makes it an attractive target for the development of new treatments. Further research is needed to fully understand the role of EMC1 in these diseases and to develop safe and effective therapies.

Protein Name: ER Membrane Protein Complex Subunit 1

Functions: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)

The "EMC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EMC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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