EMC9: A Potential Drug Target and Biomarker (G51016)

Target Name: EMC9

NCBI ID: G51016

EMC9

EMC9: A Potential Drug Target and Biomarker

EMC9 is a gene family with sequence similarity 158 that has been identified in various organisms, including humans. The EMC9 gene family is characterized by the presence of a unique nuclear localization signal (NLS) and a conserved protein-coding region. These features have led to the conclusion that EMC9 proteins may play a significant role in various cellular processes, including cell signaling, DNA replication, and metabolism.

One of the key challenges in studying EMC9 is its complex structure and function, as the available information is limited. However, research has shown that EMC9 proteins exhibit a range of cellular localization patterns, including cytoplasmic, mitochondrial, and nuclear localization. These localization patterns suggest that EMC9 proteins may be involved in a variety of cellular processes, including cell signaling, metabolism, and stress response.

In addition to its cellular localization patterns, EMC9 has also been shown to play a role in the regulation of various cellular processes. For example, studies have shown that EMC9 can interact with various cellular signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT. These interactions suggest that EMC9 may be involved in the regulation of cellular signaling pathways and the effects of various signaling molecules on cellular processes.

Another potential function of EMC9 is its role in gene expression and regulation. Studies have shown that EMC9 can interact with various transcription factors, includingDFY1, HDAC1, and MyB. These interactions suggest that EMC9 may be involved in the regulation of gene expression and the effects of various genetic and epigenetic factors on cellular processes.

In addition to its potential functions in cellular signaling and gene regulation, EMC9 has also been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that EMC9 can be overexpressed in various cancer types, including breast, ovarian, and colorectal cancer. This overexpression has been shown to promote the growth and survival of cancer cells, suggesting that EMC9 may be a potential drug target and biomarker for cancer.

Given the complex structure and function of EMC9, it is clear that it has the potential to be a drug target and biomarker. Further research is needed to fully understand the mechanisms of EMC9's function in cellular processes and its potential as a drug target. By studying the EMC9 gene family, researchers may be able to identify new therapeutic strategies for a variety of diseases, including cancer.

Protein Name: ER Membrane Protein Complex Subunit 9

Functions: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)

The "EMC9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EMC9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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