EML4's Role in Cellular Processes and Disease (G27436)

Target Name: EML4

NCBI ID: G27436

EML4

EML4's Role in Cellular Processes and Disease

EML4 (endosomal membrane protein 4) is a protein that is expressed in various cell types, including neurons, and is involved in the formation of the endosomal system. The endosomal system is a complex series of vesicles that transport and store various proteins, including drugs, in the cells. EML4 has been shown to play a role in the regulation of endosomal formation and the transport of various proteins to the endosomal system.

Recent studies have suggested that EML4 may be a drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This is because EML4 has been shown to be involved in the regulation of cellular processes that are implicated in the development and progression of these diseases.

One potential mechanism by which EML4 may be involved in the development of cancer is by regulating the delivery of drugs to the endosomal system. Many drugs are designed to be internalized into cells and then released from the endosomal system to enhance their efficacy. However, the endosomal system can also transport drugs that are toxic or potentially harmful to the cell. EML4 may play a role in regulating the delivery of drugs to the endosomal system by controlling the formation and stability of the endosomal system.

Another potential mechanism by which EML4 may be involved in the development of neurodegenerative diseases is by regulating the clearance of damaged or dysfunctional proteins from the endosomal system. The endosomal system is responsible for the delivery of proteins from the cytoplasm to the endosomal system, where they can be sorted and transported to the Golgi system for degradation. However, in neurodegenerative diseases, the endosomal system may not function properly, leading to the accumulation of damaged or dysfunctional proteins in the brain. EML4 may play a role in regulating the clearance of these proteins from the endosomal system.

In addition to its potential role in the development and progression of neurodegenerative diseases, EML4 has also been shown to be involved in the regulation of autoimmune diseases. The endosomal system has been implicated in the regulation of immune responses, and EML4 has been shown to play a role in regulating the production and presentation of antigens to the immune system.

EML4 has also been shown to have potential therapeutic applications in cancer treatment. For example, EML4 has been shown to be downregulated in various types of cancer, including breast cancer and lung cancer. This may make it a potential target for cancer therapies that aim to increase the expression of EML4. In addition, EML4 has been shown to play a role in the regulation of the sensitivity of cancer cells to chemotherapy, which may make it a potential target for cancer therapies that are designed to improve the effectiveness of chemotherapy.

In conclusion, EML4 is a protein that is involved in various cellular processes that are important for the development and progression of diseases. Recent studies have suggested that EML4 may be a drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of EML4 in these diseases and to develop effective therapies that target EML4.

Protein Name: EMAP Like 4

Functions: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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