ELMOD2: A Potential Drug Target for Neurodegenerative Diseases

Target Name: ELMOD2

NCBI ID: G255520

ELMOD2

ELMOD2: A Potential Drug Target for Neurodegenerative Diseases

ELMOD2 (Endoplasmic Reticulum-Orchestrated Module 2) is a protein that is expressed in various cell types throughout the body. Its primary function is to help regulate the movement of proteins into and out of the endoplasmic reticulum (ER), which is the cell's primary protein-folding and modification center.

ELMOD2 plays a crucial role in the ER-associated protein (ERP) network, which is a complex of proteins that help to regulate the traffic of proteins into and out of the ER. The ERP network is composed of several different subunits, including the Transmembrane Protein (TMP), the Coiled Coil-Containing Protein (CCP), and the Peripheral Membrane Protein (PM).

ELMOD2 is one of the proteins that is associated with the TMP subunit of the ERP network. It is a 21-kDa protein that is composed of a unique transmembrane region and several cytoplasmic domains. The transmembrane region of ELMOD2 is made up of a single layer of lipid bilayer membrane (phosphatidylcholine (PA) and phosphatidylinositol (PI) molecules, which are both involved in the formation of the ER-associated protein (ERP) network.

The cytoplasmic domains of ELMOD2 include a unique N-terminal region that is involved in ELMOD2's stability and function. This region is made up of a single amino acid, which is a glycine residue at position 10. The N-terminal region of ELMOD2 is also involved in its interaction with the TMP subunit of the ERP network.

ELMOD2 is a protein that is expressed in a wide variety of cell types, including neurons, muscle cells, and epithelial cells. It is also expressed in various tissues and organs, including the brain, heart, and kidneys. This suggests that ELMOD2 may be a drug target (or biomarker) that can be targeted by small molecules or other therapeutic agents in the treatment of various diseases.

In addition to its role in the ERP network, ELMOD2 is also involved in the regulation of various cellular processes that are important for cell survival and growth. For example, ELMOD2 is involved in the regulation of the cytoskeleton organization and the maintenance of cell shape, as well as in the regulation of cell signaling pathways that are important for cell growth, differentiation, and survival.

The discovery and characterization of ELMOD2 as a potential drug target (or biomarker) has important implications for the development of new therapeutic approaches for a variety of diseases. By targeting ELMOD2 with small molecules or other therapeutic agents, researchers may be able to treat a wide range of conditions, including neurodegenerative diseases, cancer, and cardiovascular disease.

In conclusion, ELMOD2 is a protein that is involved in the regulation of various cellular processes that are important for cell survival and growth. Its role in the ERP network and its expression in a wide variety of cell types make it an attractive target for small molecules or other therapeutic agents. Further research is needed to fully understand the mechanisms of ELMOD2's function and its potential as a drug target.

Protein Name: ELMO Domain Containing 2

Functions: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses

The "ELMOD2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ELMOD2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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