Target Name: ELK3
NCBI ID: G2004
Review Report on ELK3 Target / Biomarker Content of Review Report on ELK3 Target / Biomarker
ELK3
Other Name(s): ETS-related protein NET | SRF accessory protein 2 | ELK3, ETS transcription factor | ETS transcription factor ELK3 | SAP2 | ETS-domain protein | ETS domain-containing protein Elk-3 (isoform 1) | ERP | ELK3 (SAP-2) | serum response factor accessory protein 2 | ELK3, ETS-domain protein (SRF accessory protein 2) | NET | ETS transcription factor ELK3, transcript variant 1 | ETS domain-containing protein Elk-3 | ELK3 variant 1 | ETS-related protein ERP | ELK3_HUMAN | Serum response factor accessory protein 2 | SAP-2

ELK3: Potential Drug Targets and Biomarkers

ELK3 (Endoplasmic Reticulum-associated protein 3) is a protein that is expressed in various tissues and cells in the human body. Its primary function is to regulate the endoplasmic reticulum, which is a membrane-bound system that retrieves and modifies proteins before they are released into the cytoplasm. ELK3 has also been shown to play a role in the development and progression of various diseases, including cancer.

One of the unique features of ELK3 is its ability to interact with other proteins that are expressed in the endoplasmic reticulum. This interaction allows ELK3 to regulate the activity of these other proteins and to play a role in their transport and degradation. One of the most well-studied interactions of ELK3 is its association with the protein known as TRPV4 (Touch-sensitive potassium channel).

ELK3 has also been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation. For example, ELK3 has been shown to promote the survival of cancer cells and to contribute to their migration and invasion. It has also been shown to play a role in the regulation of inflammation, both by promoting the production of pro-inflammatory cytokines and by contributing to the recruitment of immune cells to the site of inflammation.

Despite the potential importance of ELK3 in various cellular processes, its role in disease remains poorly understood. However, several studies have identified potential drug targets and biomarkers for ELK3.

One potential drug target for ELK3 is its role in the regulation of the endoplasmic reticulum. By inhibiting the activity of ELK3, researchers may be able to reduce the amount of proteins that are transported into the cytoplasm, which could lead to a variety of potential therapeutic effects. For example, this could be useful for the treatment of certain diseases where the overproduction of certain proteins is thought to contribute to their development, such as cancer.

Another potential drug target for ELK3 is its role in the regulation of cell growth and apoptosis. By modulating the activity of ELK3, researchers may be able to either promote or inhibit cell growth, leading to potential therapeutic effects for a variety of diseases. For example, this could be useful for the treatment of certain types of cancer, where the uncontrolled growth of cells is thought to contribute to their development.

In addition to its potential therapeutic applications, ELK3 is also a potential biomarker for a variety of diseases. For example, ELK3 has been shown to be expressed in various types of cancer, including breast, lung, and ovarian cancer. This suggests that it may be a useful biomarker for the detection and diagnosis of these diseases.

Overall, ELK3 is a protein that has important roles in various cellular processes in the human body. While its potential therapeutic applications and biomarker potential are still being explored, its association with the regulation of the endoplasmic reticulum and its role in the regulation of cell growth and apoptosis make it a promising target for future research.

Protein Name: ETS Transcription Factor ELK3

Functions: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element

The "ELK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ELK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ELK4 | ELL | ELL2 | ELL2P1 | ELL3 | ELMO1 | ELMO2 | ELMO3 | ELMOD1 | ELMOD2 | ELMOD3 | ELN | ELOA | ELOA-AS1 | ELOA2 | ELOA3BP | ELOA3DP | ELOA3P | ELOB | ELOC | ELOF1 | Elongation Factor 1 Complex | Elongation of very long chain fatty acids protein | Elongin (SIII) complex | ELOVL1 | ELOVL2 | ELOVL2-AS1 | ELOVL3 | ELOVL4 | ELOVL5 | ELOVL6 | ELOVL7 | ELP1 | ELP2 | ELP3 | ELP4 | ELP5 | ELP6 | ELSPBP1 | EMB | EMBP1 | EMC1 | EMC1-AS1 | EMC10 | EMC2 | EMC3 | EMC3-AS1 | EMC4 | EMC6 | EMC7 | EMC8 | EMC9 | EMCN | EMD | EME1 | EME2 | EMG1 | EMID1 | EMILIN1 | EMILIN2 | EML1 | EML2 | EML2-AS1 | EML3 | EML4 | EML4-AS1 | EML5 | EML6 | EMP1 | EMP2 | EMP2P1 | EMP3 | EMSLR | EMSY | EMX1 | EMX2 | EMX2OS | EN1 | EN2 | ENAH | ENAM | ENC1 | ENDOD1 | ENDOG | Endogenous Retrovirus group K Env polyprotein (ERVK) | Endogenous retrovirus group K member 25 Pol protein-like, transcript variant X1 | EndoGlyx-1 | Endoplasmic reticulum collagen prolyl 3-hydroxylation complex | Endothelin receptor | Endothelin-Converting Enzymes (ECE) | Endothiapepsin | ENDOU | ENDOV | ENG | ENGASE | ENHO | ENKD1 | ENKUR | ENO1 | ENO1-AS1