EMC2: A Protein Implicated in Cell Survival and Disease (G9694)

Target Name: EMC2

NCBI ID: G9694

EMC2

EMC2: A Protein Implicated in Cell Survival and Disease

EMC2 (KiAA0103) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its function is not well understood, but it is known to be involved in the regulation of cell survival and proliferation. EMC2 has also been shown to play a role in the development and progression of certain diseases, including cancer. As a result, EMC2 has potential as a drug target or biomarker for a variety of diseases.

EMC2 is a member of the EMC family of proteins, which are known to be involved in the regulation of cell survival and proliferation. The EMC family includes several different proteins, including EMC1, EMC2, and EMC3. These proteins are characterized by the presence of a unique domain called the \"EMC domain,\" which is responsible for their unique functions.

One of the functions of EMC2 is to regulate the growth and survival of cells. This is accomplished through the interaction of EMC2 with several different proteins, including the transcription factor p53. When p53 is activated, it can cause EMC2 to enter a state of repression, which prevents the protein from functioning. However, if the p53 signal is removed, EMC2 can then begin to function again, allowing cells to grow and divide.

Another function of EMC2 is to regulate the regulation of cell death. This is accomplished through the interaction of EMC2 with the protein Bcl-2. When Bcl-2 is activated, it can cause EMC2 to enter a state of repression, which prevents the protein from functioning. However, if Bcl-2 is removed, EMC2 can then begin to function again, allowing cells to die when they are no longer needed.

EMC2 has also been shown to play a role in the development and progression of certain diseases, including cancer. For example, studies have shown that high levels of EMC2 are associated with poor prognosis in patients with pancreatic cancer. Additionally, EMC2 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

As a result of its involvement in these processes, EMC2 has potential as a drug target or biomarker for a variety of diseases. For example, drugs that target EMC2 have been shown to be effective in treating pancreatic cancer and other neurodegenerative diseases. Additionally, EMC2 has been shown to be involved in the regulation of cell death, which makes it a potential target for drugs that are effective in treating conditions that are characterized by inflammation and oxidative stress, such as chronic obstructive pulmonary disease (COPD) and heart failure.

In conclusion, EMC2 is a protein that is involved in the regulation of cell survival and proliferation. Its function is not well understood, but it is known to play a role in the development and progression of certain diseases, including cancer. As a result, EMC2 has potential as a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of EMC2 in these processes and to develop effective treatments.

Protein Name: ER Membrane Protein Complex Subunit 2

Functions: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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