ELOVL3: Key Enzyme in Fatty Acid Synthesis (G83401)

Target Name: ELOVL3

NCBI ID: G83401

ELOVL3

ELOVL3: Key Enzyme in Fatty Acid Synthesis

ELOVL3, also known as Very long chain 3-ketoacyl-CoA synthase 3, is a protein that plays a crucial role in the metabolism of fatty acids in the body. It is a key enzyme in the pathway of 3-ketoacyl-CoA, which is a key intermediate step in the synthesis of fatty acids from carbon sources such as carbohydrates and lipids.

The synthesis of fatty acids from carbohydrates and lipids is a vital process for maintaining cellular health and function. These compounds are not only the building blocks of muscles, bones, and other tissues, but they also play a crucial role in maintaining the insulation of the body's cells and the stability of the blood vessels. Moreover, the levels of fatty acids in the body can be affected by various factors, including diet, physical activity, and hormonal changes. Therefore, it is important to have efficient and reliable enzymes that can convert these carbon sources into the desired fatty acids.

ELOVL3 is a 1,200-amino acid protein that is localized to the endoplasmic reticulum (ER) and peroxisomal membrane (PM). It is a member of the superfamily of CoA-synthases, which are a group of enzymes that catalyze the synthesis of CoA, a crucial intermediate step in the metabolism of fatty acids. The CoA-synthases can be divided into three subfamilies, the 1-acyl-CoA synthases (ACS), the 2-acyl-CoA synthases (ACS-2), and the 3- ketoacyl-CoA synthases (KACs).

ELOVL3 is a member of the 3-ketoacyl-CoA synthase (KAC) subfamily. This subfamily is responsible for catalyzing the synthesis of the long-chain fatty acids, including the most well-known 3-ketoacyl-CoA. The 3-ketoacyl- CoA is a crucial intermediate step in the synthesis of fatty acids from carbon sources such as carbohydrates and lipids. It is a key player in the cellular metabolism, as it allows the cell to store energy in the form of fatty acids.

The 3-ketoacyl-CoA synthase (KAC) is a complex enzyme that consists of multiple subunits that are involved in the catalytic cycle. The KAC catalyzes the synthesis of 3-ketoacyl-CoA from the carbon source, such as a fatty acid or a carbohydrate. The KAC consists of three subunits, alpha, beta, and gamma subunits, which are responsible for the different stages of the synthesis cycle.

The alpha subunit is the catalytic subunit that catalyzes the synthesis of 3-ketoacyl-CoA from the carbon source. It is a key player in the catalytic cycle and has been shown to play a crucial role in the regulation of cellular processes, including cell growth , apoptosis, and inflammation.

The beta subunit is the prosthetic group subunit that interacts with the alpha subunit to regulate the activity of the enzyme. It is involved in the transfer of electrons from the carbon source to the alpha subunit during the catalytic cycle.

The gamma subunit is the modifier subunit that modifies the alpha subunit to ensure its stability and to regulate the activity of the enzyme. It is involved in the addition of a side chain to the alpha subunit, which is crucial for its stability and function.

ELOVL3 is a critical enzyme that plays a crucial role in the metabolism of fatty acids. It is a key player in the 3-ketoacyl-CoA synthesis pathway and is involved in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. Therefore, ELOVL3 may be a drug target or biomarker for various diseases, including obesity, type

Protein Name: ELOVL Fatty Acid Elongase 3

Functions: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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