ELL3: A Potential Drug Target and Biomarker for Long-Static Cellular Division

Target Name: ELL3

NCBI ID: G80237

ELL3

ELL3: A Potential Drug Target and Biomarker for Long-Static Cellular Division

Introduction

Long-static cell division is a phenomenon observed in certain cell types, including epithelial, osteogenic, and neural cells, which require uninterrupted cell division for growth and maintenance. In these cells, the rate of cell division slows down over time, leading to an increase in the size and complexity of the cells. This process is critical for the development and maintenance of tissues and organs, including skin, bone, and organs.

Recent studies have identified a key player in the regulation of long-static cell division, named ELL3 (elongation factor RNA polymerase II-like 3). ELL3 is a RNA polymerase that plays a crucial role in the regulation of gene expression and cell division. In this article, we will explore the biology of ELL3 and its potential as a drug target and biomarker.

Bioinformatics Analysis

ELL3 is an RNA polymerase involved in regulating long quiescent cell divisions. In this article, we explore the biology of LL3 and discuss its potential as a drug target and biomarker.

biophysics

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In this article, we explore the biology of LL3 and discuss its potential as a drug target and biomarker.

biochemistry

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In this article, we explore the biology of LL3 and discuss its potential as a drug target and biomarker.

molecular biology

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In this article, we explore the biology of LL3 and discuss its potential as a drug target and biomarker.

Clinical application

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In this article, we explore the biology of LL3 and discuss its potential as a drug target and biomarker.

Pharmacology

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In this article, we explore the biology of LL3 and explore its potential as a drug target and biomarker.

1. Biological functions of LL3

LL3 is an RNA polymerase involved in regulating gene expression and cell division. In eukaryotes, RNA polymerase plays a key role in the transcription process. It can recognize and bind to the promoter region of genes, thereby driving gene transcription to produce mRNA. LL3 is mainly involved in regulating the G1, S and G2 phases of the cell cycle, thereby controlling cell growth and division.

Under the catalysis of LL3, RNA polymerase II (RNA polymerase II, RNA-II) can recognize and bind to the promoter region on DNA, thereby driving gene transcription. RNA-II is a complex composed of RNA polymerase I (RNA-I) and DNA-binding protein. RNA-I is mainly involved in transcription initiation, while DNA-binding protein is responsible for binding. DNA promoter provides binding site for RNA-I.

The biological functions of LL3 are mainly reflected in the following aspects:

1. Regulate the G1, S and G2 phases of the cell cycle: LL3 participates in the G1, S and G2 phases of the cell cycle, thereby controlling cell growth and division. In the G1 phase, LL3 can bind to the DNA promoter region, thereby driving the initiation of RNA-I; in the S phase, LL3 can bind to the DNA promoter region, thereby driving the transcription of RNA-I; in the G2 phase, LL3 can bind to the DNA promoter region, thereby driving RNA-I degradation.

2. Control the stability of nuclear DNA: LL3 participates in the stability of nuclear DNA, thereby controlling the replication and repair of DNA in the nucleus. LL3 can bind to DNA

Protein Name: Elongation Factor For RNA Polymerase II 3

Functions: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968)

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