DHRSX: A Potential Drug Target and Biomarker for Dehydrogenase/Reductase SDR Family Members

Target Name: DHRSX

NCBI ID: G207063

DHRSX

DHRSX: A Potential Drug Target and Biomarker for Dehydrogenase/Reductase SDR Family Members

Dehydrogenase/reductase SDR family members are a group of enzymes involved in the detoxification and metabolism of xenobiotics, such as environmental toxins and drugs. These enzymes are crucial for maintaining cellular homeostasis and are involved in various cellular processes, including DNA replication, cell signaling, and stress response. DHRSX, a member of the SDR family, is a key enzyme involved in the detoxification of xenobiotics.

In this article, we will discuss DHRSX as a potential drug target and biomarker for DHRSX-mediated diseases. We will review the current literature on DHRSX and its functions, as well as its potential as a drug target and biomarker.

Current Knowledge of DHRSX

DHRSX is a member of the SDR family, which includes several enzymes involved in the detoxification and metabolism of xenobiotics. DHRSX is a 23-kDa protein that is expressed in various tissues, including the liver, kidney, and intestine. It is highly conserved and has a similar structure to other SDR family members, including XDRS (Dihydrolipoyl Transacetylase) and GDRS (Dihydrolipoyl Reductase).

DHRSX functions as a critical enzyme in the detoxification of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), which are found in various environmental toxins, including polycyclic aromatic compounds (PACs), which are generated by combustion, industrial processes, and other sources. DHRSX converts the toxic metabolite 2,3-dihydroxy-2-methylpropionitrile (2,3-DHPC) to a less toxic metabolite, 2,3-dihydroxy-2-methylpropionate (2,3-DHP), which is then excreted in the urine and feces.

DHRSX is also involved in the detoxification of other xenobiotics, including a variety of pesticides and environmental toxins. It has been shown to be a powerful antioxidant and to protect cells from oxidative stress caused by these toxins.

Potential Drug Target

DHRSX is a potential drug target due to its involvement in the detoxification of xenobiotics and its antioxidant properties. Several studies have shown that inhibiting DHRSX can lead to reduced detoxification of these toxins and increased toxicity.

One of the main targets of DHRSX is the xenobiotic 2,3-DHPC, which is a metabolite of thePAC2024. In animal models, DHRSX has been shown to reduce the detoxification of 2,3-DHPC when exposed to thePAC2024. This suggests that DHRSX may be a useful target for the development of drugs that can improve the detoxification of environmental toxins.

Another potential target of DHRSX is its antioxidant properties. DHRSX has been shown to protect cells from oxidative stress caused by a variety of xenobiotics and environmental toxins. This suggests that DHRSX may be a useful target for the development of drugs that can protect cells from oxidative stress.

Biomarker

DHRSX has been shown to be involved in various cellular processes, including DNA replication, cell signaling, and stress response. This suggests that it may be a useful biomarker for tracking the effects of drugs on these processes.

One approach to using DHRSX as a biomarker is to measure the levels of DHRSX in tissues or fluids after exposure to a drug. This can be done using techniques such as qRT-PCR (Quantitative Real-Time Polymerase Chain Reaction) or mass spectrometry (MS), which allow for the quantification of specific protein sequences in the DNA or RNA.

Another approach to using DHRSX as a biomarker is to measure the response of cellular processes, such as DNA replication or cell signaling, to a drug. This can be done using techniques such as cell-based assays or in vitro assays, which allow for the assessment of specific cellular processes.

Conclusion

DHRSX is a key enzyme involved in the detoxification of xenobiotics and has been shown to have a variety of cellular functions. As a result, it is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of DHRSX in cellular processes and its potential as a drug target and biomarker.

Protein Name: Dehydrogenase/reductase X-linked

Functions: Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851)

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•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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