ALDH3A1 and Disease Research (G218)

Target Name: ALDH3A1

NCBI ID: G218

ALDH3A1

ALDH3A1 and Disease Research

ALDH3A1 (ALDH3), also known as NAD+-dependent aldehyde dehydrogenase 3A1 (NAD+-ALDH3), is a gene that encodes a protein involved in the metabolism of lipids and xenobiotics. The encoded protein, ALDH3A1, is a member of the NAD+-dependent aldehyde dehydrogenase (NAD+-ADH) superfamily and is primarily located on the nuclear perichromosome 15q21 region of chromosome 15.

The ALDH3A1 protein is expressed in many tissues and is involved in the detoxification of a variety of xenobiotics, including environmental toxins and medications. It is a critical enzyme in the detoxification pathway for many compounds, including polycyclic aromatic hydrocarbons (PAHs), polycyclic nitrogen compounds (PCNs), and heterocyclic amines (HCAs), which are known to be potential causes of cancer and other diseases.

In addition to its role in xenobiotic detoxification, ALDH3A1 is also involved in the metabolism of lipids and has been shown to play a role in the regulation of lipid metabolism. It is a key enzyme in the fatty acid oxidation pathway, which is involved in the breakdown of fatty acids from food sources and their conversion to energy.

The ALDH3A1 gene has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Several studies have identified mutations in the ALDH3A1 gene as being associated with various diseases, including cancer. For example, a study published in the journal Nature Communications found that mutations in the ALDH3A1 gene were significantly overrepresented in primary brain tumors (PBTs) compared to the general population.

Another study published in the journal Oncogene found that ALDH3A1 mutations were frequently observed in tumors that were associated with poor prognosis, including pancreatic, colorectal, and ovarian cancers. Additionally, a study published in the journal PLoS Medicine found that individuals with certain genetic variations, including those in the ALDH3A1 gene, were at increased risk of developing multiple sclerosis.

Despite the potential implications of ALDH3A1 mutations in diseases, very little is known about the specific functions of the ALDH3A1 protein in the context of these diseases. Further research is needed to understand the precise role of ALDH3A1 in disease and to develop new treatments or biomarkers based on this protein.

In conclusion, ALDH3A1 is a gene that encodes a protein involved in a critical detoxification pathway for many xenobiotics and is also involved in the regulation of lipid metabolism. The encoded protein has been implicated in a number of diseases, including cancer and neurodegenerative disorders. Further research is needed to understand the specific functions of ALDH3A1 in disease and to develop new treatments or biomarkers based on this protein.

Protein Name: Aldehyde Dehydrogenase 3 Family Member A1

Functions: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)

The "ALDH3A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ALDH3A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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