Mitochondrial Translation Initiation Factor (MTIF3) (G219402)

Target Name: MTIF3

NCBI ID: G219402

MTIF3

Mitochondrial Translation Initiation Factor (MTIF3)

Mitochondria are organelles that are responsible for generating the energy-producing molecules, called ATP, for the entire cell. They are also involved in the maintenance of cellular homeostasis and are crucial for the survival of eukaryotic cells. The Mitochondrial Translation Initiation Factor (MTIF3) is a protein that is expressed in high levels in the mitochondria and is involved in the initiation of protein translation.

MTIF3 is a key protein that is required for the proper functioning of the mitochondria. It plays a critical role in the initiation of protein translation by interacting with the mTOR complex, which is a complex of transcription factors that regulates the expression of genes. The mTOR complex is composed of the following components:

* MapKat (MapKAT2)
* TOR (TOR1)
* P700
* P900

MTIF3 interacts with the mTOR complex through its N-terminus, where it forms a complex with the protein known as SIRT1 (Sirtuin 1). SIRT1 is a non-protein coding RNA that has been shown to have a variety of cellular functions, including the regulation of protein translation.

MTIF3 has been shown to play a critical role in the regulation of protein translation by the mTOR complex. Studies have shown that MTIF3 interacts with SIRT1 and that this interaction is necessary for the proper functioning of the mTOR complex. Additionally, studies have shown that MTIF3 is involved in the regulation of protein translation by the mTOR complex in a variety of cellular contexts, including the regulation of cell growth, metabolism, and stress resistance.

Because of its involvement in the regulation of protein translation by the mTOR complex, MTIF3 has potential as a drug target or biomarker. Researchers are currently working to develop compounds that can inhibit the activity of MTIF3 and prevent its interaction with SIRT1. These compounds may have a variety of potential therapeutic applications, including the treatment of various diseases, such as cancer, diabetes, and neurodegenerative disorders.

In conclusion, MTIF3 is a protein that is expressed in high levels in the mitochondria and plays a critical role in the initiation of protein translation by the mTOR complex. It has potential as a drug target or biomarker due to its involvement in the regulation of protein translation and its interaction with SIRT1. Further research is needed to fully understand the role of MTIF3 in cellular function and its potential as a therapeutic target.

Protein Name: Mitochondrial Translational Initiation Factor 3

Functions: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins

The "MTIF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTIF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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