Target Name: FIS1
NCBI ID: G51024
Review Report on FIS1 Target / Biomarker Content of Review Report on FIS1 Target / Biomarker
FIS1
Other Name(s): Fis1 homolog | hFis1 | FIS1 homolog | FIS1_HUMAN | Fission, mitochondrial 1 | fission 1 (mitochondrial outer membrane) homolog | Tetratricopeptide repeat protein 11 | TTC11 | mitochondrial fission molecule | fission, mitochondrial 1 | CGI-135 | Mitochondrial fission 1 protein | TPR repeat protein 11 | tetratricopeptide repeat domain 11 | H_NH0132A01.6 | tetratricopeptide repeat protein 11

FIS1: A Key Regulator of The Actinin Complex and Potential Drug Targets

FIS1 (Fis1 homolog) is a gene that encodes a protein known as FIS1, which is a key regulator of the actinin complex in eukaryotic cells. The actinin complex is a complex of actinin proteins that play a crucial role in the cytoskeleton and cell division. FIS1 is highly conserved across various species, and it has been implicated in various cellular processes, including cell division, migration, and intracellular signaling.

Drug Target and Biomarker

FIS1 has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its involvement in these diseases has led to the development of various compounds that target FIS1 and have been shown to enhance the inhibition of FIS1- mediated signaling pathways. These compounds have been shown to have therapeutic potential in preclinical models of these diseases.

FIS1 has also been identified as a potential biomarker for several diseases, including cancer and neurodegenerative diseases. Its expression has been shown to be affected in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. These studies have led to the development of biomarkers that can be used to diagnose and monitor these diseases.

Functions and Interactions

FIS1 is a key regulator of the actinin complex, which is a complex of actinin proteins that play a crucial role in the cytoskeleton and cell division. The actinin complex is composed of various subunits, including A, B, and C, which are involved in the regulation of cell division, differentiation, and intracellular signaling.

FIS1 is involved in the regulation of the actinin complex through its interaction with several other proteins, including tubulin, and myosin. FIS1 has been shown to interact with tubulin and tubulin, which are important proteins involved in the regulation of microtubules. These interactions are important for the proper functioning of the actinin complex and the regulation of cell division and differentiation.

FIS1 is also involved in the regulation of intracellular signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular signaling and is important for the regulation of various cellular processes, including cell survival, growth, and differentiation.

Biomarkers

FIS1 has been identified as a potential biomarker for several diseases, including cancer and neurodegenerative diseases. Its expression has been shown to be affected in these diseases, and its levels have been shown to be increased in the brains of individuals with these diseases.

For example, studies have shown that FIS1 levels are increased in the brains of individuals with Alzheimer's disease, and that these levels are also increased in the brains of individuals with other neurodegenerative diseases. These studies suggest that FIS1 may be a potential biomarker for these diseases and that its levels may be used as a diagnostic tool for these conditions.

Drugs Targeting FIS1

FIS1 has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its involvement in these diseases has led to the development of various compounds that target FIS1 and have been shown to enhance the inhibition of FIS1- mediated signaling pathways.

One of the most well-known compounds that targets FIS1 is the drug sunitinib, which is used to treat

Protein Name: Fission, Mitochondrial 1

Functions: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892)

The "FIS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FIS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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