N4BP3: A Potential Drug Target and Biomarker (G23138)

Target Name: N4BP3

NCBI ID: G23138

N4BP3

Other Name(s): LZTS4 | NEDD4 binding protein 3 | N4BP3_HUMAN | NEDD4-binding protein 3

N4BP3: A Potential Drug Target and Biomarker

Introduction

N4BP3 (LZTS4) is a protein that is expressed in various tissues and cell types in the human body. Its function and structure have been well-studied, and it has been identified as a potential drug target and biomarker. In this article, we will explore the research on N4BP3 and its potential as a drug target and biomarker.

Potential Drug Target

N4BP3 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. N4BP3 is a protein that is composed of four domains: a N-terminal alpha-helix, a central beta-sheet, a C- terminal hypervariable region (HVR), and a second N-terminal alpha-sheet. The N-terminal and C-terminal domains contain conserved structural features that are commonly found in proteins that are involved in various cellular processes.

One of the key features of N4BP3 is its ability to interact with various protein substrates, including tyrosine, histidine, and serine. This interaction with protein substrates suggests that N4BP3 may be a protein-tyrosine phosphatase (PTPase), an enzyme that regulates the tyrosine phosphorylation of various protein substrates. Additionally, N4BP3 has been shown to interact with the protein PDGF-BB, which is a potent regulator of cell proliferation and survival.

In addition to its interaction with protein substrates, N4BP3 has also been shown to play a role in the regulation of cellular processes such as cell adhesion, migration, and invasion. These functions are critical for the development and progression of various diseases, including cancer. Therefore, N4BP3 may be an attractive drug target for the treatment of these diseases.

Potential Biomarkers

N4BP3 has also been identified as a potential biomarker for various diseases. For example, N4BP3 has been shown to be overexpressed in various cancer types, including breast, ovarian, and prostate cancer. This overexpression is associated with poor prognosis and increased disease severity. Therefore , N4BP3 may be a useful biomarker for the diagnosis and prognosis of cancer.

In addition to its use as a cancer biomarker, N4BP3 may also be used as a biomarker for other diseases. For example, N4BP3 has been shown to be overexpressed in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. This overexpression is associated with the development of these disorders and may be a potential diagnostic or therapeutic target.

Conclusion

In conclusion, N4BP3 is a protein that has been well-studied due to its potential as a drug target and biomarker. Its unique structure and interaction with various protein substrates suggest that N4BP3 may be involved in the regulation of various cellular processes. Additionally, its involvement in the regulation of cancer and neurological disorders makes it an attractive target for the development of new therapies. Further research is needed to fully understand the function and potential of N4BP3 as a drug target and biomarker.

Protein Name: NEDD4 Binding Protein 3

Functions: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity)

The "N4BP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about N4BP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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