Understanding The Potential Role of NAA60 in Human Diseases (G79903)

Target Name: NAA60

NCBI ID: G79903

NAA60

Understanding The Potential Role of NAA60 in Human Diseases

NAA60 (NAA60_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the nuclear transport chain and is involved in the transport of various molecules, including nucleotides, across the nuclear membrane. The NAA60 protein has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including cell division, apoptosis, and metabolism.

NAA60 is a 60 kDa protein that is expressed in various tissues of the human body, including the brain, heart, and liver. It is a member of the nuclear transport chain and is involved in the transport of various molecules across the nuclear membrane, including nucleotides, proteins, and small molecules. The NAA60 protein has four known isoforms, which are different in their primary structure and expression levels.

One of the unique features of the NAA60 protein is its ability to interact with various signaling molecules, including TGF-β, NF-kappa-B, and p53. This interaction with these signaling molecules has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and metabolism.

In addition to its role in signaling pathways, NAA60 has also been shown to play a role in the regulation of cellular processes that are important for maintaining tissue homeostasis. For example, studies have shown that NAA60 is involved in the regulation of cell division and that it plays a role in the regulation of cell cycle progression.

The potential drug target status of NAA60 is due to its ability to interact with various signaling molecules and its involvement in the regulation of cellular processes that are important for maintaining tissue homeostasis. This suggests that NAA60 may be a useful target for the development of new pharmaceuticals for a variety of diseases, including cancer, cardiovascular disease, and metabolism.

In conclusion, NAA60 is a protein that is expressed in various tissues of the human body and is involved in the regulation of various cellular processes, including cell division, apoptosis, and metabolism. Its interaction with various signaling molecules and its role in maintaining tissue homeostasis make NAA60 a potential drug target for the development of new pharmaceuticals for a variety of diseases. Further research is needed to fully understand the role of NAA60 in biological processes and to develop effective treatments for diseases in which it is involved.

Protein Name: N-alpha-acetyltransferase 60, NatF Catalytic Subunit

Functions: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917)

The "NAA60 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NAA60 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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