NAMPT: A Drug Target / Disease Biomarker (G10135)

Target Name: NAMPT

NCBI ID: G10135

NAMPT

NAMPT: A Drug Target / Disease Biomarker

NAMPT (Nucleotide-Amide Piperazole Transferase) is a enzyme that plays a crucial role in the biosynthesis of nucleotides, which are the building blocks of DNA and RNA. Nucleotides are essential molecules for the development and maintenance of life, as they carry genetic information. Therefore, any molecule that modifies or influences nucleotide biosynthesis could be a drug target or biomarker.

NAMPT is a member of the nucleotide transporter family 3 (NUPT), which is responsible for transporting various nucleotides across the membrane of the cell. NAMPT is a peripheral protein that can be found in various cell types, including bacteria, archaea, and eukaryotes. It has a single transmembrane domain and a nucleotide-binding oligomerization (NBO) domain that is responsible for nucleotide transport.

The NAMPT enzyme has several unique features that make it a potential drug target or biomarker. One of its defining features is its catalytic mechanism, which involves a nucleotide-amide transfer. This transfer occurs through a specific conformation of the enzyme, which allows it to efficiently transport nucleotides across the membrane. The NAMPT enzyme has a high catalytic rate and a low Michaelis constant, which indicates that it is a fast and efficient nucleotide transporter.

Another feature that makes NAMPT an attractive drug target is its role in the production of nucleotides, which are often used as drug targets or biomarkers. Many drugs work by modulating nucleotide biosynthesis or by inhibiting the activity of nucleotide transporters. Since NAMPT is involved in nucleotide transport, it is a potential target for drugs that affect nucleotide biosynthesis or transport. For example, inhibitors of the NAMPT enzyme have been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and genetic disorders.

In addition to its potential as a drug target, NAMPT also has implications as a biomarker. The NAMPT enzyme is involved in the production of many different nucleotides, which means that it can be used as a marker for various cellular processes, including DNA replication, gene expression, and cellular stress. Therefore, measuring the levels of NAMPT in cells or tissues can be a useful tool for studying cellular processes and conditions. For example, high levels of NAMPT have been observed in cells under stress, which may indicate that the cells are undergoing DNA damage repair or other cellular processes that require the production of nucleotides.

Another potential application of NAMPT as a biomarker is its ability to be used in multiplexed assays. NAMPT is often used in combination with other enzymes or probes to study complex cellular processes, such as DNA replication, transcription, or translation. By using NAMPT as a biomarker in these assays, researchers can determine which factors are most involved in a particular cellular process and gain insights into the underlying mechanisms that are responsible for these processes.

In conclusion, NAMPT is a unique and fascinating enzyme that plays a crucial role in the biosynthesis of nucleotides. Its catalytic mechanism, its role in nucleotide production, and its potential as a drug target or biomarker make it an attractive target for researchers to study. As research continues to advance, the potential applications of NAMPT as a drug or biomarker will become more clear.

Protein Name: Nicotinamide Phosphoribosyltransferase

Functions: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity)

The "NAMPT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NAMPT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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