NAA11: A Protein of Interest for Cancer and Inflammation (G84779)

Target Name: NAA11

NCBI ID: G84779

NAA11

NAA11: A Protein of Interest for Cancer and Inflammation

NAA11 (Neutrophil-associated protein 11) is a protein that is expressed in high levels in the cells of the immune system, particularly neutrophils. It is a member of the P1 domain family and is found in various cell types, including blood cells, epithelial cells, and other immune cells. NAA11 has been shown to play a number of important roles in the immune system, including its role in the regulation of inflammation and its involvement in the development of various diseases. As a result, NAA11 has become a focus of interest for researchers and may be a potential drug target or biomarker.

The NAA11 protein is composed of 156 amino acid residues and has a molecular weight of 19.1 kDa. It is expressed in a variety of tissues and cells, including blood cells, where it is highly represented. NAA11 is primarily localized to the cytoplasm of neutrophils, where it is involved in the regulation of various cellular processes, including the immune response, cell signaling, and metabolism.

One of the key functions of NAA11 is its role in the regulation of inflammation. Neutrophils are a type of white blood cell that play a central role in the immune response to infection and inflammation. NAA11 is involved in the recruitment of neutrophils to sites of infection or inflammation, as well as in the regulation of their activities. For example, studies have shown that NAA11 can inhibit the activation and recruitment of neutrophils, and can also modulate their functions, such as their ability to produce pro-inflammatory cytokines. These findings suggest that NAA11 may be a potential drug target or biomarker for the treatment of inflammatory diseases.

In addition to its role in inflammation, NAA11 is also involved in the regulation of cell signaling and metabolism. It is a member of the TIGER-type family, which is characterized by the presence of a unique C-terminal region that is involved in protein-protein interactions. This region has been shown to play a role in the regulation of cell signaling, including the production of signaling molecules such as tyrosine and phosphoproteins. NAA11 is also involved in the regulation of cellular metabolism, including the metabolism of nutrients and the production of energy.

The NAA11 protein has also been shown to be involved in the development of various diseases, including cancer. Studies have shown that NAA11 is often overexpressed in cancer cells, and that this overexpression can contribute to the development and progression of cancer. For example, one study found that NAA11 was overexpressed in human breast cancer cells and that this overexpression was associated with the development of cancer-promoting effects. Another study also found that NAA11 was overexpressed in lung cancer cells and that this overexpression was associated with the development of cancer-promoting effects. These findings suggest that NAA11 may be a potential biomarker or drug target for the treatment of cancer.

In conclusion, NAA11 is a protein that is expressed in high levels in the cells of the immune system and is involved in a number of important functions, including the regulation of inflammation, cell signaling, and metabolism. Its role in these processes makes NAA11 a focus of interest for researchers and may make it a potential drug target or biomarker. Further studies are needed to fully understand the functions of NAA11 and its potential as a drug or biomarker.

Protein Name: N-alpha-acetyltransferase 11, NatA Catalytic Subunit

Functions: Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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