KLHL15: A Protein Involved in Cellular Stress Responses and Signaling Pathways

Target Name: KLHL15

NCBI ID: G80311

KLHL15

KLHL15: A Protein Involved in Cellular Stress Responses and Signaling Pathways

KLHL15 (KIAA1677) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a member of the heat shock protein (HSP) family, which are proteins that are expressed in response to increased levels of thermal stress in the body.

KLHL15 is unique among its family members because of its ability to interact with and modulate the activity of other proteins. This interaction with other proteins is known as a \"domino\" effect, in which one protein's activity can trigger a cascade of changes in the activity of other proteins.

One of the KLHL15's most significant functions is its role in the regulation of cellular stress responses. When the body is exposed to stressors, such as infection or damage, KLHL15 helps to coordinate the cellular responses to these stressors. This is done by interacting with other stress-responsive proteins and regulating their activity.

KLHL15 has also been shown to play a role in the regulation of cellular signaling pathways that are involved in cell growth, differentiation, and survival. This includes the regulation of the PI3K/Akt signaling pathway, which is involved in the production of signaling molecules that promote cell growth and survival.

In addition to its role in cellular stress responses and signaling pathways, KLHL15 has also been shown to be involved in the regulation of inflammation. This is done by its interaction with the immune system and its ability to modulate the activity of immune cells.

KLHL15 is also of interest as a potential drug target. Its unique ability to interact with and modulate the activity of other proteins makes it a promising target for small molecules. Additionally, its role in the regulation of cellular stress responses and signaling pathways makes it a potential target for drugs that are aimed at preventing or treating cellular stress-related diseases.

Overall, KLHL15 is a protein that is of great interest due to its unique ability to interact with and modulate the activity of other proteins. Its role in cellular stress responses and signaling pathways, as well as its potential as a drug target, make it a promising target for the development of new treatments for a variety of cellular stress-related diseases.

Protein Name: Kelch Like Family Member 15

Functions: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:27561354, PubMed:14528312, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381)

The "KLHL15 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KLHL15 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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