FZR1: A Protein Implicated in Cellular Processes and Diseases

Target Name: FZR1

NCBI ID: G51343

FZR1

FZR1: A Protein Implicated in Cellular Processes and Diseases

FZR1 (Farnesyltransferase Z-like 1) is a protein that is expressed in various tissues throughout the body. It is a key player in the regulation of cell growth and differentiation, and is involved in the process of farnesylation, which is the modification of proteins with farnesyl groups. This modification is important for the regulation of cellular processes such as cell growth, survival, and migration.

FZR1 has been identified as a potential drug target due to its involvement in the regulation of cell growth and differentiation. Studies have shown that FZR1 plays a role in the regulation of cell proliferation, and that it is involved in the development of various diseases, including cancer. Additionally, FZR1 has been shown to be involved in the regulation of cell survival, and that its levels are often decreased in cancer cells.

FZR1 is also involved in the regulation of cellular migration, which is the movement of cells towards a new location. This is important for the development and progression of various diseases, including cancer. Additionally, FZR1 is involved in the regulation of cell adhesion, which is the stickiness of cells to other cells and the formation of tight junctions between cells. This is important for the regulation of tissue structure and function.

FZR1 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and gastrointestinal tract. It is primarily localized to the cytoplasm of cells, where it is involved in the regulation of cellular processes such as cell growth, differentiation, and survival.

Studies have shown that FZR1 is involved in the regulation of cell growth and differentiation. It has been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that FZR1 is involved in the regulation of cell proliferation in cancer cells, and that it is often decreased in these cells. Additionally, FZR1 has been shown to be involved in the regulation of cell survival in cancer cells, and that its levels are often decreased in these cells.

FZR1 is also involved in the regulation of cellular migration, which is the movement of cells towards a new location. This is important for the development and progression of various diseases, including cancer. For example, studies have shown that FZR1 is involved in the regulation of cell migration in cancer cells, and that it plays a role in the development of these diseases.

Additionally, FZR1 is involved in the regulation of cell adhesion, which is the stickiness of cells to other cells and the formation of tight junctions between cells. This is important for the regulation of tissue structure and function. For example, studies have shown that FZR1 is involved in the regulation of cell adhesion in various tissues, including the brain and the heart.

Overall, FZR1 is a protein that is involved in a wide range of cellular processes that are important for the development and progression of various diseases. As such, it is a potential drug target, and research into its role in these processes may provide valuable insights into the development of new treatments for these diseases.

Protein Name: Fizzy And Cell Division Cycle 20 Related 1

Functions: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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