Study of EIF4E1B: Unraveling Its Functions and Potential Applications

Target Name: EIF4E1B

NCBI ID: G253314

EIF4E1B

Other Name(s): EIF4E1B variant 2 | eukaryotic translation initiation factor 4E family member 1B | I4E1B_HUMAN | Eukaryotic translation initiation factor 4E family member 1B, transcript variant 2 | Eukaryotic translation initiation factor 4E type 1B

Study of EIF4E1B: Unraveling Its Functions and Potential Applications

EIF4E1B (EIF4E1B variant 2) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a member of the EIF4 family, which includes several similar proteins that play important roles in cell signaling. One of the key functions of EIF4E1B is to regulate the formation of new blood vessels, which is essential for the growth and development of tissues.

In addition to its role in blood vessel formation, EIF4E1B is also involved in several other cellular processes. For example, it has been shown to play a role in the regulation of cell death, and it has been shown to interact with several different signaling pathways.

Despite its widespread expression, little is known about the specific functions of EIF4E1B. One of the main challenges in studying this protein is its complex structure. Because it is a transmembrane protein, it is not easily purified from cells and has not been shown to interact with small molecules in a cell-free format.

In order to study the functions of EIF4E1B more fully, researchers have used a variety of techniques to try to determine its specific role in cellular processes. One approach has been to use RNA interference experiments to knock down the expression of EIF4E1B in cells and study the effects on various cellular processes.

For example, researchers have used RNA interference to knock down the expression of EIF4E1B in cancer cells and have found that this has an impact on the growth and survival of these cells. They have also used RNA interference to knock down the expression of EIF4E1B in neurons and have found that this has an impact on the structure and function of these cells.

Another approach that researchers have used to study the functions of EIF4E1B is to use live cell imaging techniques to visualize the localization of this protein in different cellular contexts. For example, researchers have used fluorescence microscopy to visualize the localization of EIF4E1B in the brain and have found that this protein is concentrated in the axons of neurons.

While much research has been done to study the functions of EIF4E1B, there is still much to be learned. For example, it is not known exactly how EIF4E1B interacts with other proteins in the cell, or what the full range of its functions is. There is also a need for more research on the specific cellular processes that are regulated by EIF4E1B.

In conclusion, EIF4E1B (EIF4E1B variant 2) is a protein that is widely expressed in various tissues of the body and is involved in several important cellular processes. While much research has been done to study its functions, there is still much to be learned about this protein and its role in the cell. Further studies are needed to fully understand the specific functions of EIF4E1B and to determine its potential as a drug target or biomarker.

Protein Name: Eukaryotic Translation Initiation Factor 4E Family Member 1B

Functions: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure

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